Comparative effectiveness of antihypertensive treatment for older children with primary hypertension: study protocol for a series of n-of-1 randomized trials

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• 作者：Joyce P. Samuel ; Joshua A. Samuels ; Lauren E. Brooks ; Cynthia S. Bell…
• 关键词：Antihypertensive medications ; N ; of ; 1 trial ; Pediatrics ; Hypertension ; Comparative effectiveness research
• 刊名：Trials
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：680 KB
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• 作者单位：Joyce P. Samuel (1)
  Joshua A. Samuels (1)
  Lauren E. Brooks (2)
  Cynthia S. Bell (1)
  Claudia Pedroza (1)
  Donald A. Molony (3)
  Jon E. Tyson (1)
  
  1. Division of Pediatric Nephrology and Hypertension, University of Texas Health Science Center at Houston (UTHealth) McGovern Medical School, 6431 Fannin, MSB 3.121, Houston, Texas, 77030, USA
  2. UTHealth McGovern Medical School, Houston, Texas, USA
  3. Division of Renal Diseases and Hypertension, UTHealth McGovern Medical School, Houston, Texas, USA
  
• 刊物主题：Medicine/Public Health, general; Biomedicine general; Statistics for Life Sciences, Medicine, Health Sciences;
• 出版者：BioMed Central
• ISSN：1745-6215

文摘

Background Children are increasingly being diagnosed with primary hypertension. The absence of comparative effectiveness research of antihypertensive medications in children has contributed to considerable differences in prescribing practices among physicians treating children with primary hypertension. Even if parallel-group trials had established a best overall choice for most of these children, the best medication for an individual may differ from the best overall medication.