Hepatic S1P deficiency lowers plasma cholesterol levels in apoB-containing lipoproteins when LDLR function is compromised

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• 作者：Debapriya Basu ; Afroza Huq ; Jahangir Iqbal ; M. Mahmood Hussain…
• 关键词：S1P ; Knockdown ; cre ; Blp ; c ; Ad libitum ; LDLR ; PCSK9 ; SREBP ; Hepatocytes
• 刊名：Nutrition & Metabolism
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：12
• 期：1
• 全文大小：1,848 KB
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Nutrition
  Metabolic Diseases
  Clinical Nutrition
  
• 出版者：BioMed Central
• ISSN：1743-7075

文摘

Background Site-1 protease (S1P) is the key enzyme required for activation of the sterol regulatory element binding proteins (SREBPs) that govern lipid synthesis. While S1P has been speculated to influence plasma apoB-containing lipoprotein (Blp) metabolism, there has been little investigative work. LDL receptor (LDLR) is the major receptor for clearing plasma LDL cholesterol (LDL-c). Proprotein convertase subtilisin kexin type 9 (PCSK9) modulates LDL-c through post-translational degradation of the LDLR.