Free fatty acids, not triglycerides, are associated with non-alcoholic liver injury progression in high fat diet induced obese rats

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• 作者：Jiali Liu ; Lina Han ; Leilei Zhu ; Yerong Yu
• 关键词：Non ; alcoholic fatty liver disease ; Free fatty acids ; Triglycerides ; Oxidative stress ; Lipid metabolism
• 刊名：Lipids in Health and Disease
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：1
• 全文大小：2,236 KB
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• 作者单位：Jiali Liu (1)
  Lina Han (1)
  Leilei Zhu (1)
  Yerong Yu (1)
  
  1. Department of Endocrinology and Metabolism, West China Hospital, Sichuan University, Guoxue lane 37, Chengdu, Sichuan, 610041, China
  
• 刊物主题：Lipidology; Medical Biochemistry;
• 出版者：BioMed Central
• ISSN：1476-511X

文摘

Background The incidence of non-alcoholic fatty liver disease (NAFLD), commonly associated with obesity and metabolic syndrome, is increasing worldwide. However, the specific mechanisms that mediate the progression from simple steatosis to non-alcoholic steatohepatitis remain largely unclear. This study aimed to investigate the timedependent changes of triglyceride (TG) and free fatty acid (FFA) levels in the blood and liver over 24 weeks in high-fat diet-induced obese rats with NAFLD and to clarify the role of high FFA levels in the progression of liver injury.