A Case of Uterine Leiomyoma with Intravenous Leiomyomatosis—Histological Investigation of the Pathological Condition-

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• 作者：Asami Fukuyama (1)
  Yoshihito Yokoyama (1)
  Masayuki Futagami (1)
  Tatsuhiko Shigeto (1)
  Ryuichi Wada (2)
  Hideki Mizunuma (1)
  
• 关键词：CD ; 34 antibody ; Immunostaining ; Intravenous leiomyomatosis ; Pathological genesis ; Uterine leiomyoma
• 刊名：Pathology & Oncology Research
• 出版年：2011
• 出版时间：March 2011
• 年：2011
• 卷：17
• 期：1
• 页码：171-174
• 全文大小：359KB
• 参考文献：1. Norris HJ, Parmley T (1975) Mesenchymal tumors of the uterus. Intravenous leiomyomatosis. A clinical and pathologic study of 14 cases. Cancer 36:2146-178
  2. Timmis AD, Smallpeice C, Davies AC et al (1980) Intracardiac spread of intravenous leiomyomatosis with successful surgical excision. N Engl J Med 303:1043-044 CrossRef
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  4. Lam PM, Lo KW, Yu MY et al (2004) Intravenous leiomyomatosis: two cases with different routes of tumor extension. J Vasc Surg 39:465-69 CrossRef
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  10. Mitsuhashi A, Nagai Y, Sugita M et al (1999) GnRH agonist for intravenous leiomyomatosis eith cardiac extension. A case report. J Reprod Med 44:883-86
  
• 作者单位：Asami Fukuyama (1)
  Yoshihito Yokoyama (1)
  Masayuki Futagami (1)
  Tatsuhiko Shigeto (1)
  Ryuichi Wada (2)
  Hideki Mizunuma (1)
  
  1. Department of Obstetrics and Gynecology, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan
  2. Department of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, 5-Zaifu-cho, Hirosaki, Aomori, 036-8562, Japan
  
• ISSN：1532-2807

文摘

Intravenous leiomyomatosis (IVL) is generally defined as a histologically benign leiomyoma derived from a uterine myoma or intrauterine venous wall that has grown and extended intravenously. We here report on a single case of IVL, and investigate its pathological genesis. Regarding the part of the myoma extending to the vessel lumen, observations found the myoma to be pushing into the vessel. Immunostaining with CD34 antibody gave an image of the area where the myoma pushed into the vessel, showing CD34-positive vessel endothelium cells folded back into a layer covering the myoma, and continuing to line of the surface of the myoma within the vessel. Early pathological genesis of IVL was clarified for the first time that the tumor did not invade the vessel by breaking the venous wall, but rather advanced by stretching the vascular wall and progressing into the vein like a polyp, covered in endothelium cells.