Atypical uterine leiomyoma: a case report and review of the literature

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• 作者：Suzana Manxhuka-Kerliu ; Irma Kerliu-Saliu…
• 关键词：Atypical uterine leiomyoma ; Histology ; Immunohistochemistry ; Prognostic markers
• 刊名：Journal of Medical Case Reports
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：10
• 期：1
• 全文大小：818 KB
• 参考文献：1.Sung CO, Ahn G, Song SY. Atypical leiomyomas of the uterus with long-term follow-up after myomectomy with immunohistochemical analysis for p16INK4A, p53, Ki-67, estrogen receptors, and progesterone receptors. Int J Gynecol Pathol. 2009;28(6):529–34.CrossRef PubMed
  2.Prayson RA, Hart WR. Pathologic considerations of uterine smooth muscle tumors. Obstet Gynecol Clin North Am. 1995;22(4):637–57.PubMed
  3.Fattaneh A. Tavassoli Peter Devilee: Pathology and genetics of tumours of the breast and female genital organs, vol. Chapter 4. Lyon: IARC Press; 2003. p. 241.
  4.Ip PP, Cheung AN, Clement PB. Uterine smooth muscle tumors of uncertain malignant potential (STUMP): a clinicopathologic analysis of 16 cases. Am J Surg Pathol. 2009;33(7):992–1005.CrossRef PubMed
  5.Bodner-Adler B, Bodner K, Czerwenka K. Expression of p16 protein in patients with uterine smooth muscle tumors: an immunohistochemical analysis. Gynecol Oncol. 2005;96(1):62–6.CrossRef PubMed
  6.O’Neill CJ, McBride HA, Connolly LE. Uterine leiomyosarcomas are characterized by high p16, p53 and MIB1 expression in comparison with usual leiomyomas, leiomyoma variants and smooth muscle tumours of uncertain malignant potential. Histopathology. 2007;50(7):851–8.CrossRef PubMed
  7.Atkins KA, Arronte N, Darus CJ. The use of p16 in enhancing the histologic classification of uterine smooth muscle tumors. Am J Surg Pathol. 2008;32(1):98–102.CrossRef PubMed
  8.Ly A, Mills AM, McKenney JK. Atypical leiomyomas of the uterus: a clinicopathologic study of 51 cases. Am J Surg Pathol. 2013;37(5):643–9.CrossRef PubMed
  9.Mills AM, Ly A, Balzer BL. Cell cycle regulatory markers in uterine atypical leiomyoma and leiomyosarcoma: immunohistochemical study of 68 cases with clinical follow-up. Am J Surg Pathol. 2013;37(5):634–42.CrossRef PubMed
  10.Ünver NU, Acikalin MF, Öner Ü. Differential expression of P16 and P21 in benign and malignant uterine smooth muscle tumors. Arch Gynecol Obstet. 2011;284(2):483–90.CrossRef PubMed
  11.Bodner K, Bodner-Adler B, Kimberger O. Bcl-2 receptor expression in patients with uterine smooth muscle tumors: an immunohistochemical analysis comparing leiomyoma, uterine smooth muscle tumor of uncertain malignant potential, and leiomyosarcoma. J Soc Gynecol Investig. 2004;11(3):187–91.CrossRef PubMed
  12.Bodner K, Bodner-Adler B, Kimberger O. Estrogen and progesterone receptor expression in patients with uterine smooth muscle tumors. Fertil Steril. 2004;81(4):1062–6.CrossRef PubMed
  13.Mayerhofer K, Lozanov P, Bodner K. Ki-67 expression in patients with uterine leiomyomas, uterine smooth muscle tumors of uncertain malignant potential (STUMP) and uterine leiomyosarcomas (LMS). Acta Obstet Gynecol Scand. 2004;83(11):1085–8.CrossRef PubMed
  14.Petrović D, Babić D, Forko JI. Expression of Ki-67, P53 and progesterone receptors in uterine smooth muscle tumors. Diagnostic value. Coll Antropol. 2010;34(1):93–7.PubMed
  15.Hewedi IH, Radwan NA, Shash LS. Diagnostic value of progesterone receptor and p53 expression in uterine smooth muscle tumors. Diagn Pathol. 2012;7:1.PubMedCentral CrossRef PubMed
  16.Niemann TH, Raab SS, Lenel JC. p53 protein overexpression in smooth muscle tumors of the uterus. Hum Pathol. 1995;26(4):375–9.CrossRef PubMed
  
• 作者单位：Suzana Manxhuka-Kerliu (1)
  Irma Kerliu-Saliu (2)
  Vjollca Sahatciu-Meka (3)
  Lloreta Kerliu (2)
  Labinot Shahini (1)
  
  1. Faculty of Medicine, Institute of Pathology, University of Prishtina, Mother Theresa Street NN, 10 000, Prishtina, Kosovo
  2. Massachusetts College of Pharmacy and Health Sciences (MCPHS), 179 Longwood Avenue, Boston, MA, 02115, USA
  3. Faculty of Medicine, University of Prishtina, Mother Theresa Street NN, 10 000, Prishtina, Kosovo
  
• 刊物主题：Medicine/Public Health, general; General Practice / Family Medicine; Public Health; Primary Care Medicine;
• 出版者：BioMed Central
• ISSN：1752-1947

文摘

Background Atypical uterine leiomyomas show benign behavior. However, the distinction between leiomyomas and leiomyosarcomas may at times be problematic. We report a rare case of atypical uterine leiomyoma. We try to investigate potential immunohistochemical parameters that could be essential to distinguish cases of malignant smooth muscle tumors and those of uncertain or borderline histology.