Radiographic hand osteoarthritis and serum levels of osteocalcin: cross-sectional study

详细信息    查看全文

• 作者：Leonid Kalichman (1)
  Eugene Kobyliansky (2)
  
• 关键词：Hand ; Osteoarthritis ; Osteocalcin ; Bone
• 刊名：Rheumatology International
• 出版年：2010
• 出版时间：June 2010
• 年：2010
• 卷：30
• 期：8
• 页码：1131-1135
• 全文大小：233KB
• 参考文献：1. Lawrence RC, Helmick CG, Arnett FC, Deyo RA, Felson DT, Giannini EH, Heyse SP, Hirsch R, Hochberg MC, Hunder GG, Liang MH, Pillemer SR, Steen VD, Wolfe F (1998) Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States. Arthritis Rheum 41:778-99. doi:10.1002/1529-0131(199805)41:5<778:AID-ART4>3.0.CO;2-V CrossRef
  2. Buckwalter JA, Martin J, Mankin HJ (2000) Synovial joint degeneration and the syndrome of osteoarthritis. Instr Course Lect 49:481-89
  3. Sokoloff L (1987) Osteoarthritis as a remodeling process. J Rheumatol 14 Spec no:7-0
  4. Ghosh P, Smith M (2002) Osteoarthritis, genetic and molecular mechanisms. Biogerontology 3:85-8 CrossRef
  5. Lajeunesse D, Hilal G, Pelletier JP, Martel-Pelletier J (1999) Subchondral bone morphological and biochemical alterations in osteoarthritis. Osteoarthritis Cartilage 7:321-22. doi:10.1053/joca.1998.0180 CrossRef
  6. Martel-Pelletier J (1999) Pathophysiology of osteoarthritis. Osteoarthritis Cartilage 7:371-73. doi:10.1053/joca.1998.0214 CrossRef
  7. Melton LJ 3rd, Khosla S, Atkinson EJ, O’Fallon WM, Riggs BL (1997) Relationship of bone turnover to bone density and fractures. J Bone Miner Res 12:1083-091 CrossRef
  8. Garcia-Carrasco M, Gruson M, de Vernejoul MC, Denne MA, Miravet L (1988) Osteocalcin and bone morphometric parameters in adults without bone disease. Calcif Tissue Int 42:13-7 CrossRef
  9. Hodgkinson A, Thompson T (1982) Measurement of the fasting urinary hydroxyproline: creatinine ratio in normal adults and its variation with age and sex. J Clin Pathol 35:807-11 CrossRef
  10. Campion GV, Delmas PD, Dieppe PA (1989) Serum and synovial fluid osteocalcin (bone gla protein) levels in joint disease. Br J Rheumatol 28:393-98 CrossRef
  11. Gevers G, Dequeker J (1987) Collagen and non-collagenous protein content (osteocalcin, sialoprotein, proteoglycan) in the iliac crest bone and serum osteocalcin in women with and without hand osteoarthritis. Coll Relat Res 7:435-42
  12. Garnero P, Piperno M, Gineyts E, Christgau S, Delmas PD, Vignon E (2001) Cross sectional evaluation of biochemical markers of bone, cartilage, and synovial tissue metabolism in patients with knee osteoarthritis: relations with disease activity and joint damage. Ann Rheum Dis 60:619-26 CrossRef
  13. Wang Y, Ebeling PR, Hanna F, O’Sullivan R, Cicuttini FM (2005) Relationship between bone markers and knee cartilage volume in healthy men. J Rheumatol 32:2200-204
  14. Bruyere O, Collette JH, Ethgen O, Rovati LC, Giacovelli G, Henrotin YE, Seidel L, Reginster JY (2003) Biochemical markers of bone and cartilage remodeling in prediction of longterm progression of knee osteoarthritis. J Rheumatol 30:1043-050
  15. Sowers M, Lachance L, Jamadar D, Hochberg MC, Hollis B, Crutchfield M, Jannausch ML (1999) The associations of bone mineral density and bone turnover markers with osteoarthritis of the hand and knee in pre- and perimenopausal women. Arthritis Rheum 42:483-89. doi:10.1002/1529-0131(199904)42:3<483:AID-ANR13>3.0.CO;2-O CrossRef
  16. El’chinova GI, Znichenko RA, Ginter EK (2003) Temporal dynamics of ethnic assortativeness in the Tsivil’sk region of Chuvashia. Genetika 39:562-64
  17. Pavlovsky O (1981) Methods of osseographic studies of the bone. In: Pavlovsky O (ed) Morpho-physiological researches in anthropology. MGU Publishing House, Moscow, pp 44-1
  18. Kellgren J, Lawrence J (1963) Atlas of standard radiographs: the epidemiology of chronic rheumatism. Blackwell, Oxford
  19. Altman RD, Gold GE (2007) Atlas of individual radiographic features in osteoarthritis, revised. Osteoarthr Cartil 15(Suppl A):A1–A56. doi:10.1016/j.joca.2006.11.009 CrossRef
  20. Kalichman L, Kobyliansky E (2009) Hand osteoarthritis in Chuvashian population: prevalence and determinants. Rheumatol Int 30:85-2. doi:10.1007/s00296-009-0920-9 CrossRef
  21. Kalichman L, Li L, Kobyliansky E (2009) Prevalence, pattern and determinants of radiographic hand osteoarthritis in Turkmen community-based sample. Rheumatol Int 29:1143-149. doi:10.1007/s00296-008-0815-1 CrossRef
  22. Dequeker J, Mokassa L, Aerssens J (1995) Bone density and osteoarthritis. J Rheumatol Suppl 43:98-00
  23. Sharif M, George E, Dieppe PA (1995) Correlation between synovial fluid markers of cartilage and bone turnover and scintigraphic scan abnormalities in osteoarthritis of the knee. Arthritis Rheum 38:78-1 CrossRef
  24. Stewart A, Black A, Robins SP, Reid DM (1999) Bone density and bone turnover in patients with osteoarthritis and osteoporosis. J Rheumatol 26:622-26
  25. Kalichman L, Cohen Z, Kobyliansky E, Livshits G (2004) Patterns of joint distribution in hand osteoarthritis: contribution of age, sex, and handedness. Am J Hum Biol 16:125-34. doi:10.1002/ajhb.20007 CrossRef
  
• 作者单位：Leonid Kalichman (1)
  Eugene Kobyliansky (2)
  
  1. Department of Physical Therapy, Recanati School for Community Health Professions, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O.B. 653, 84105, Beer Sheva, Israel
  2. Research Unit, Human Population Biology, Department of Anatomy and Anthropology, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
  

文摘

The objective of this study is to evaluate the association between radiographic hand osteoarthritis and serum level of osteocalcin. The study population comprised Chuvashians (285 males, age 47.38?±?16.79; 265 females, age 48.55?±?15.94?years). OA was evaluated for 14 joints of each hand using Kellgren and Lawrence (K–L), joint space narrowing (JSN) and osteophytes (OS) scores. Plasma-intact osteocalcin was measured in 550 individuals by immunoradiometric assay using ELSA-OSTEO kit. Statistical analyses included multiple linear and logistic regressions.?51.64% of studied individuals had at least one finger joint affected at K–L ? level. JSN at the level ? was found in 9.82% and OS ? was found in 35.09% of the studied individuals. Osteocalcin showed a modest, but statistically significant, association with the number of affected joints according the K–L scale (beta?=?0.082, p?=?0.015), JSN scale (beta?=?0.097, p?=?0.025) and OS scale (beta?=?0.078, p?=?0.029). No significant association was found between the presence of at least one affected joint (K–L?≥? or OS?≥?) and serum level of osteocalcin. Presence of at least one joint with space narrowing ? was significantly associated with serum level of osteocalcin (beta?=?0.052, p?=?0.023). In this cross-sectional population-based study, we found that serum level of osteocalcin is positively associated with severity of hand OA, measured by K–L, JSN and OS scales.