Network-based expression analysis reveals key genes related to glucocorticoid resistance in infant acute lymphoblastic leukemia

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• 作者：Zaynab Mousavian ; Abbas Nowzari-Dalini ; Ronald W. Stam…
• 关键词：Acute lymphoblastic leukemia ; Glucocorticoid treatment ; Drug resistance ; Systems biology ; Gene co ; expression network
• 刊名：Cellular Oncology
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：40
• 期：1
• 页码：33-45
• 全文大小：
• 刊物主题：Cancer Research; Biomedicine, general; Pathology; Oncology;
• 出版者：Springer Netherlands
• ISSN：2211-3436
• 卷排序：40

文摘

PurposeDespite vast improvements that have been made in the treatment of children with acute lymphoblastic leukemia (ALL), the majority of infant ALL patients (~80 %, < 1 year of age) that carry a chromosomal translocation involving the mixed lineage leukemia (MLL) gene shows a poor response to chemotherapeutic drugs, especially glucocorticoids (GCs), which are essential components of all current treatment regimens. Although addressed in several studies, the mechanism(s) underlying this phenomenon have remained largely unknown. A major drawback of most previous studies is their primary focus on individual genes, thereby neglecting the putative significance of inter-gene correlations. Here, we aimed at studying GC resistance in MLL-rearranged infant ALL patients by inferring an associated module of genes using co-expression network analysis. The implications of newly identified candidate genes with associations to other well-known relevant genes from the same module, or with associations to known transcription factor or microRNA interactions, were substantiated using literature data.