High-frequency sensorineural hearing loss in patients with ankylosing spondylitis: is it an extrarticuler feature of disease?

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• 作者：Mehmet Adam (1)
  Alper Nabi Erkan (2)
  Didem Arslan (3)
  Berrin Leblebici (1)
  Levent ?zlüo?lu (2)
  M. Nafiz Akman (1)
  
• 关键词：Ankylosing spondylitis ; Sensorineural hearing loss ; High frequency
• 刊名：Rheumatology International
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：28
• 期：5
• 页码：413-417
• 全文大小：305KB
• 参考文献：1. Davis CD (2005) Ankylosing spondylitis. In: Koopman WJ, Moreland LW (eds) Arthritis and allied conditions: a textbook of rheumatology. Lippincott, Williams & Wilkins, Philadelphia, pp 1319-334
  2. Vernon-Roberts B (2003) Ankylosing spondylitis: pathology. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH (eds) Rheumatology. Mosby, Barcelona, pp 1205-210
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  17. Savastano M, Marioni G, Bernini G, Punzi L (2005) Tinnitus and bilateral sensorineural hearing loss: ankylosing spondylitis or a side-effect of sulphasalazine treatment? Acta Otolaryngol 125(6):671-
  
• 作者单位：Mehmet Adam (1)
  Alper Nabi Erkan (2)
  Didem Arslan (3)
  Berrin Leblebici (1)
  Levent ?zlüo?lu (2)
  M. Nafiz Akman (1)
  
  1. Department of Physical Medicine and Rehabilitation, Baskent University Faculty of Medicine, Dadaloglu Mah. 39 Sok. No:6, 01250, Yuregir, Adana, Turkey
  2. Department of Oto-rhinolaringology, Baskent University Faculty of Medicine, Ankara, Turkey
  3. Department of Rheumatology, Baskent University Faculty of Medicine, Ankara, Turkey
  

文摘

Objective The aim of this study was to investigate the ear involvement, especially at extended higher frequencies than those previously studied, in patients with ankylosing spondylitis (AS). Patients and methods We prospectively evaluated 45 consecutive patients with AS. All patients underwent a complete physical examination of the ear, nose, and throat and an audiologic evaluation that included pure-tone audiometry at conventional and extended high frequencies, the determination of a speech discrimination score and the uncomfortable loudness level, and impedance audiometry. Thirty healthy volunteers were included as controls. Results The mean age of the patients was 39.6?±?9.1?years (range 19-3?years) and that of the controls was 10.6?±?8.1?years (range 1-0?years). There was no statistically significant difference between the two groups with respect to conventional frequency air conduction threshold and bone conduction threshold. There was a statistically significant difference at 14,000-6,000?Hz at extended high frequencies in 32 patients with AS (71.1%) versus 12 controls (40%). At 14,000-6,000?Hz, eight patients demonstrated a sensorineural hearing loss caused by extraspinal involvement. There was a significant difference between the patients with or without extraspinal involvement, and a positive correlation was noted between the duration of disease and the hearing level at 10,000-6,000?Hz. Conclusion Sensorineural hearing loss, especially at extended high frequencies, is common in patients with AS and may be an extra-articular feature of that disease. A long duration of disease and extraspinal involvement are important parameters for ear involvement in patients with AS.