Harnessing the immune system for the treatment of breast cancer
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- 作者：Xinguo Jiang (1)
- 关键词：Breast cancer ; Chronic inflammation ; Protumorigenic immune cells ; Therapeutic vaccines ; Immunotherapy ; R737.9 ; 涔宠吅鐧?/li> 鎱㈡€х値鐥囧弽搴?/li> 淇冭偪鐦ゅ彂灞曞厤鐤粏鑳?/li> 鑲跨槫鐤嫍 ; 鍏嶇柅娌荤枟
- 刊名：Journal of Zhejiang University SCIENCE B
- 出版年：2014
- 出版时间：January 2014
- 年：2014
- 卷：15
- 期：1
- 页码：1-15
- 全文大小：536 KB
- 作者单位：Xinguo Jiang (1)
1. Department of Medicine, VA Palo Alto Health Care System/Stanford University School of Medicine, Stanford, CA, 94305, USA - ISSN：1862-1783
文摘
Standard treatment options for breast cancer include surgery, chemotherapy, radiation, and targeted therapies, such as adjuvant hormonal therapy and monoclonal antibodies. Recently, the recognition that chronic inflammation in the tumor microenvironment promotes tumor growth and survival during different stages of breast cancer development has led to the development of novel immunotherapies. Several immunotherapeutic strategies have been studied both preclinically and clinically and already have been shown to enhance the efficacy of conventional treatment modalities. Therefore, therapies targeting the immune system may represent a promising next-generation approach for the treatment of breast cancers. This review will discuss recent findings that elucidate the roles of suppressive immune cells and proinflammatory cytokines and chemokines in the tumor-promoting microenvironment, and the most current immunotherapeutic strategies in breast cancer.