Intracoronary infusion of Wharton's jelly-derived mesenchymal stem cells in acute myocardial infarction: double-blind, randomized controlled trial
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- 作者：Lian R Gao ; Yu Chen ; Ning K Zhang ; Xi L Yang ; Hui L Liu ; Zhi G Wang…
- 关键词：Myocardial infarction ; Mesenchymal stem cells ; Wharton’s jelly of umbilical cord
- 刊名：BMC Medicine
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：13
- 期：1
- 全文大小：1,286 KB
- 刊物主题：Medicine/Public Health, general; Biomedicine general;
- 出版者：BioMed Central
- ISSN：1741-7015
文摘
Background The use of adult stem cells is limited by the quality and quantity of host stem cells. It has been demonstrated that Wharton’s jelly–derived mesenchymal stem cells (WJMSCs), a primitive stromal population, could integrate into ischemic cardiac tissues and significantly improve heart function. In this randomized, controlled trial, our aim was to assess the safety and efficacy of intracoronary WJMSCs in patients with ST-elevation acute myocardial infarction (AMI).