Association between the XRCC1 Arg194Trp polymorphism and risk of cancer: evidence from 201 case–control studies

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• 作者：Yan-Zhong Feng (1)
  Yi-Ling Liu (2)
  Xiao-Feng He (3)
  Wu Wei (3)
  Xu-Liang Shen (4)
  Dao-Lin Xie (5)
  
• 关键词：XRCC1 ; Arg194Trp ; Polymorphism ; Susceptibility ; Meta ; analysis ; Cancer
• 刊名：Tumor Biology
• 出版年：2014
• 出版时间：November 2014
• 年：2014
• 卷：35
• 期：11
• 页码：10677-10697
• 全文大小：790 KB
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• 作者单位：Yan-Zhong Feng (1)
  Yi-Ling Liu (2)
  Xiao-Feng He (3)
  Wu Wei (3)
  Xu-Liang Shen (4)
  Dao-Lin Xie (5)
  
  1. Department of maternity, Peace Hospital of Changzhi Medical College, Changzhi, 046000, China
  2. Department of Blood Transfusion, Sun Yat-sen Memorial Hopital, Sun Yat-sen University, Guangzhou, 510120, China
  3. Department of Research, Peace Hospital of Changzhi Medical College, Changzhi, 046000, China
  4. Department of Hematology, Peace Hospital of Changzhi Medical College, Changzhi, 046000, China
  5. Department of Ultrasound diagnosis, Peace Hospital of Changzhi Medical College, Changzhi, 046000, China
  
• ISSN：1423-0380

文摘

The Arg194Trp polymorphism in the X-ray cross-complementing group 1 (XRCC1) had been implicated in cancer susceptibility. The previous published data on the association between XRCC1 Arg194Trp polymorphism and cancer risk remained controversial. Hence, we performed a meta-analysis to investigate the association between cancer susceptibility and XRCC1 Arg194Trp (59,227 cases and 81,587 controls from 201 studies) polymorphism in different inheritance models. We used odds ratios with 95?% confidence intervals to assess the strength of the association. Overall, significantly increased cancer risk was found (recessive model: (odds ration [OR]--.18, 95?% confidence interval [CI]--.09-.27; homozygous model: OR--.21, 95?% CI--.10-.33; additive model: OR--.05, 95?% CI--.01-.09) when all eligible studies were pooled into the meta-analysis. In further stratified and sensitivity analyses, significantly increased glioma risk was found among Asians, significantly decreased lung cancer risk was found among Caucasians, and significant increased breast cancer risk was found among hospital-based studies. In summary, this meta-analysis suggests that Arg194Trp polymorphism may be associated with increased breast cancer risk, Arg194Trp polymorphism is associated with increased glioma risk among Asians, and Arg194Trp polymorphism is associated with decreased lung cancer risk among Caucasians. In addition, our work also points out the importance of new studies for Arg194Trp association in some cancer types, such as gastric, pancreatic, prostate, and nasopharyngeal cancers, where at least some of the covariates responsible for heterogeneity could be controlled, to obtain a more conclusive understanding about the function of the XRCC1 Arg194Trp polymorphism in cancer development (I 2--5?%).