The effect of kinin B1 receptor on chronic itching sensitization
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- 作者：Yuying Liu ; Jianhua Liu ; Mengran Li ; Sailin Dai ; Jiexian Liang ; Wenjin Ji
- 关键词：Chronic itch ; Bradykinin B1 receptor ; Keratinocytes cells ; HaCaT cell lines
- 刊名：Molecular Pain
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：11
- 期：1
- 全文大小：1,665 KB
- 刊物主题：Pain Medicine; Molecular Medicine;
- 出版者：BioMed Central
- ISSN：1744-8069
文摘
Background Altered kallikrein-related peptidase activity and bradykinin are associated with skin disorders in humans and mice under chronic inflammation conditions. The bradykinin B1 receptor (B1R), also known as one of the G-protein-coupled receptor family and usually absent in intact tissues and upregulated during tissue injury, is responsible for vasodilation, capillary permeability, nociceptor sensitization, and pain; it is indispensable for physiopathological progress in chronic inflammation conditions, but its roles and effectors in the itching sensation of the allergic contact dermatitis model are poorly defined.