PICALM Gene rs3851179 Polymorphism Contributes to Alzheimer’s Disease in an Asian Population

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• 作者：Guiyou Liu (1) (2)
  Shuyan Zhang (3)
  Zhiyou Cai (7)
  Guoda Ma (1)
  Liangcai Zhang (4)
  Yongshuai Jiang (4)
  Rennan Feng (5)
  Mingzhi Liao (4)
  Zugen Chen (6)
  Bin Zhao (7)
  Keshen Li (1) (7)
  
• 关键词：Alzheimer’s disease ; Genome ; wide association studies ; PICALM gene rs3851179 polymorphism ; Caucasian ; Asian
• 刊名：NeuroMolecular Medicine
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：15
• 期：2
• 页码：384-388
• 全文大小：334KB
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  2. Chen, L. H., Kao, P. Y., Fan, Y. H., Ho, D. T., Chan, C. S., Yik, P. Y., et al. (2012). Polymorphisms of CR1, CLU and PICALM confer susceptibility of Alzheimer’s disease in a southern Chinese population. / Neurobiology of Aging, / 33(1), 210 e211-10 e217.
  3. Harold, D., Abraham, R., Hollingworth, P., Sims, R., Gerrish, A., Hamshere, M. L., et al. (2009). Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer’s disease. / Nature Genetics, / 41(10), 1088-093. CrossRef
  4. Hollingworth, P., Harold, D., Sims, R., Gerrish, A., Lambert, J. C., Carrasquillo, M. M., et al. (2011). Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer’s disease. / Nature Genetics, / 43(5), 429-35. CrossRef
  5. Jiang, Y., Zhang, R., Zheng, J., Liu, P., Tang, G., Lv, H., et al. (2012). Meta-analysis of 125 rheumatoid arthritis-related single nucleotide polymorphisms studied in the past two decades. / PLoS ONE, / 7(12), e51571. CrossRef
  6. Jun, G., Naj, A. C., Beecham, G. W., Wang, L. S., Buros, J., Gallins, P. J., et al. (2010). Meta-analysis confirms CR1, CLU, and PICALM as Alzheimer disease risk loci and reveals interactions with APOE genotypes. / Archives of Neurology, / 67(12), 1473-484. CrossRef
  7. Lee, J. H., Cheng, R., Barral, S., Reitz, C., Medrano, M., Lantigua, R., et al. (2011). Identification of novel loci for Alzheimer disease and replication of CLU, PICALM, and BIN1 in Caribbean Hispanic individuals. / Archives of Neurology, / 68(3), 320-28. CrossRef
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  9. Liu, G., Zhang, L., Feng, R., Liao, M., Jiang, Y., Chen, Z., et al. (2013). Lack of association between PICALM rs3851179 polymorphism and Alzheimer’s disease in Chinese population and APOEepsilon4-negative subgroup. / Neurobiology of Aging, / 34(4), 1310 e1319-310 e1310.
  10. Logue, M. W., Schu, M., Vardarajan, B. N., Buros, J., Green, R. C., Go, R. C., et al. (2011). A comprehensive genetic association study of Alzheimer disease in African Americans. / Archives of Neurology, / 68(12), 1569-579. CrossRef
  11. Naj, A. C., Jun, G., Beecham, G. W., Wang, L. S., Vardarajan, B. N., Buros, J., et al. (2011). Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer’s disease. / Nature Genetics, / 43(5), 436-41. CrossRef
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• 作者单位：Guiyou Liu (1) (2)
  Shuyan Zhang (3)
  Zhiyou Cai (7)
  Guoda Ma (1)
  Liangcai Zhang (4)
  Yongshuai Jiang (4)
  Rennan Feng (5)
  Mingzhi Liao (4)
  Zugen Chen (6)
  Bin Zhao (7)
  Keshen Li (1) (7)
  
  1. Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China
  2. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Beijing, China
  3. Department of Neurology, The Fourth Affiliated Hospital, Harbin Medical University, Harbin, 150001, China
  7. Key Laboratory of Aging-Related Cardio-Cerebral Diseases of Guangdong Province, Affiliated Hospital of Guangdong Medical College, Zhanjiang, 524001, China
  4. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
  5. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China
  6. Department of Human Genetics, University of California at Los Angeles, Los Angeles, CA, USA
  

文摘

PICALM gene rs3851179 polymorphism was reported to an Alzheimer’s disease (AD) susceptibility locus in a Caucasian population. However, recent studies reported consistent and inconsistent results in an Asian population. Four studies indicated no association between rs3851179 and AD in a Chinese population and one study reported weak association in a Japanese population. We consider that the failure to replicate the significant association between rs3851179 and AD may be caused by at least two reasons. The first reason may be the genetic heterogeneity in AD among different populations, and the second may be the relatively small sample size compared with large-scale GWAS in Caucasian ancestry. In order to confirm this view, in this research, we first evaluated the genetic heterogeneity of rs3851179 polymorphism in Caucasian and Asian populations. We then investigated rs3851179 polymorphism in an Asian population by a pooled analysis method and a meta-analysis method. We did not observe significant genetic heterogeneity of rs3851179 in the Caucasian and Asian populations. Our results indicate that rs3851179 polymorphism is significantly associated with AD in the Asian population by both pooled analysis and meta-analysis methods. We believe that our findings will be very useful for future genetic studies in AD.