Analyzing Large-Scale Samples Confirms the Association Between the ABCA7 rs3764650 Polymorphism and Alzheimer’s Disease Susceptibility
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- 作者：Guiyou Liu (1) (2)
Fujun Li (3)
Shuyan Zhang (4)
Yongshuai Jiang (5)
Guoda Ma (1)
Hong Shang (4)
Jiafeng Liu (6)
Rennan Feng (7)
Liangcai Zhang (8)
Mingzhi Liao (5)
Bin Zhao (9)
Keshen Li (1) (9) - 关键词：ABCA7 rs3764650 polymorphism ; Alzheimer’s disease ; Genome ; wide association studies
- 刊名：Molecular Neurobiology
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：50
- 期：3
- 页码：757-764
- 全文大小：774 KB
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Yongshuai Jiang (5)
Guoda Ma (1)
Hong Shang (4)
Jiafeng Liu (6)
Rennan Feng (7)
Liangcai Zhang (8)
Mingzhi Liao (5)
Bin Zhao (9)
Keshen Li (1) (9)
1. Institute of Neurology, Guangdong Medical College, Zhanjiang, 524001, China
2. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Xiqi Dao 32, Tianjin Airport Economic Area, Tianjin, 300308, China
3. Department of Anesthesiology, The First Affiliated Hospital, Harbin Medical University, Harbin, China
4. Department of Neurology, The Forth Affiliated Hospital of Harbin Medical University, Harbin, China
5. College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, China
6. Department of Neurology, The First Hospital of Harbin, Harbin, China
7. Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, Harbin, China
8. Department of Statistics, Rice University, Houston, TX, USA
9. Key Laboratory of Aging-Related Cardio-Cerebral Diseases of Guangdong Province, Affiliated Hospital of Guangdong Medical College, Zhanjiang, China - ISSN：1559-1182
文摘
Large-scale genome-wide association studies (GWAS) have revealed that the ABCA7 rs3764650 polymorphism (or its proxies, namely rs115550680, rs3752246, and rs4147929) is associated with Alzheimer’s disease (AD) susceptibility in individuals of Caucasian ancestry. The following studies have investigated this finding in Chinese (N--33 and N--,224), Japanese (N--,735), Korean (N--44), African American (N--,896), and Canadian (N--,104) populations. However, these studies reported a weak or negligible association. We hypothesized that these negative results may have been caused by either relatively small sample sizes compared with those used for the previous GWAS in individuals of Caucasian ancestry or the genetic heterogeneity of the rs3764650 polymorphism (or its proxies) in different populations. Here, we reevaluated the association between rs3764650 and AD using large-scale samples from 18 previous studies (N--9,381-0,590 cases and 48,791 controls) by searching PubMed, AlzGene, and Google Scholar databases. Using allele, dominant, recessive, and additive models, we did not identify significant heterogeneity among the 18 studies. We observed a significant association between rs3764650 and AD using the allele (P--.76E??-6, odds ratio (OR)--.21, 95?% confidence interval (CI) 1.17-.26), dominant (P--.00E??-4, OR--.17, 95?% CI 1.07-.28), recessive (P--.00E??-3, OR--.43, 95?% CI 1.13-.81), and additive models (P--.00E??-3, OR--.49, 95?% CI 1.16-.91). Collectively, our analysis further supports previous findings that the ABCA7 rs3764650 polymorphism is associated with AD susceptibility. We believe that our findings will be very useful for future genetic studies on AD.