Lack of association between the G+2044A polymorphism of interleukin-13 gene and chronic obstructive pulmonary disease: a meta-analysis

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• 作者：Lian Duan ; Rui Liang ; Zhendong Wang ; Lei Lei ; Lianhong Jin…
• 关键词：IL ; 13 ; G+2044A ; Polymorphism ; Chronic obstructive pulmonary disease ; Association
• 刊名：Molecular Biology Reports
• 出版年：2014
• 出版时间：September 2014
• 年：2014
• 卷：41
• 期：9
• 页码：6297-6303
• 全文大小：239 KB
• 参考文献：1. Hogg JC, Timens W (2009) The pathology of chronic obstructive pulmonary disease. Annu Rev Pathol 4:435-59 CrossRef
  2. Lopez AD, Shibuya K, Rao C, Mathers CD, Hansell AL, Held LS, Schmid V, Buist S (2006) Chronic obstructive pulmonary disease: current burden and future projections. Eur Respir J 27(2):397-12 CrossRef
  3. Trajkov D, Mirkovska-Stojkovikj J, Petlichkovski A, Strezova A, Efinska-Mladenovska O, Sandevska E, Sibinovska O, Hristomanova S, Djulejic E, Petrov J, Gogusev J, Spiroski M (2009) Association of cytokine gene polymorphisms with chronic obstructive pulmonary disease in Macedonians. Iran J Allergy Asthma Immunol 8(1):31-2
  4. Pauwels RA, Rabe KF (2004) Burden and clinical features of chronic obstructive pulmonary disease (COPD). Lancet 364(9434):613-20 CrossRef
  5. Pauwels RA, Buist AS, Calverley PM, Jenkins CR, Hurd SS (2001) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop summary. Am J Respir Crit Care Med 163(5):1256-276
  6. Rabe KF, Hurd S, Anzueto A, Barnes PJ, Buist SA, Calverley P, Fukuchi Y, Jenkins C, Rodriguez-Roisin R, van Weel C, Zielinski J (2007) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 176(6):532-55
  7. Lokke A, Lange P, Scharling H, Fabricius P, Vestbo J (2006) Developing COPD: a 25?year follow up study of the general population. Thorax 61(11):935-39 CrossRef
  8. Vestbo J, Hurd SS, Agusti AG, Jones PW, Vogelmeier C, Anzueto A, Barnes PJ, Fabbri LM, Martinez FJ, Nishimura M, Stockley RA, Sin DD, Rodriguez-Roisin R (2013) Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary. Am J Respir Crit Care Med 187(4):347-65
  9. Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM (2006) Global burden of COPD: systematic review and meta-analysis. Eur Respir J 28(3):523-32 CrossRef
  10. Wang X, Li L, Xiao J, Jin C, Huang K, Kang X, Wu X, Lv F (2009) Association of ADAM33 gene polymorphisms with COPD in a northeastern Chinese population. BMC Med Genet 10:132 CrossRef
  11. Rennard SI (2004) Treatment of stable chronic obstructive pulmonary disease. Lancet 364(9436):791-02 CrossRef
  12. Sadeghnejad A, Meyers DA, Bottai M, Sterling DA, Bleecker ER, Ohar JA (2007) IL13 promoter polymorphism 1112C/T modulates the adverse effect of tobacco smoking on lung function. Am J Respir Crit Care Med 176(8):748-52
  13. Fletcher C, Peto R (1977) The natural history of chronic airflow obstruction. Br Med J 1(6077):1645-648 CrossRef
  14. Sethi JM, Rochester CL (2000) Smoking and chronic obstructive pulmonary disease. Clin Chest Med 21 (1):67-6, viii
  15. Mannino DM, Homa DM, Akinbami LJ, Ford ES, Redd SC (2002) Chronic obstructive pulmonary disease surveillance—United States, 1971-000. MMWR Surveill Summ 51(6):1-6
  16. Smolonska J, Wijmenga C, Postma DS, Boezen HM (2009) Meta-analyses on suspected chronic obstructive pulmonary disease genes: a summary of 20?years-research. Am J Respir Crit Care Med 180(7):618-31
  17. Nakamura H (2011) Genetics of COPD. Allergol Int 60(3):253-58 CrossRef
  18. Castaldi PJ, Cho MH, Cohn M, Langerman F, Moran S, Tarragona N, Moukhachen H, Venugopal R, Hasimja D, Kao E, Wallace B, Hersh CP, Bagade S, Bertram L, Silverman EK, Trikalinos TA (2010) The COPD genetic association compendium: a comprehensive online database of COPD genetic associations. Hum Mol Genet 19(3):526-34 CrossRef
  19. Tashkin DP, Altose MD, Connett JE, Kanner RE, Lee WW, Wise RA (1996) Methacholine reactivity predicts changes in lung function over time in smokers with early chronic obstructive pulmonary disease. The Lung Health Study Research Group. Am J Respir Crit Care Med 153(6 Pt 1):1802-811
  20. Postma DS, Kerstjens HA (1998) Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease. Am J Respir Crit Care Med 158(5 Pt 3):S187–S192
  21. Hospers JJ, Postma DS, Rijcken B, Weiss ST, Schouten JP (2000) Histamine airway hyper-responsiveness and mortality from chronic obstructive pulmonary disease: a cohort study. Lancet 356(9238):1313-317 CrossRef
  22. Marsh DG, Neely JD, Breazeale DR, Ghosh B, Freidhoff LR, Ehrlich-Kautzky E, Schou C, Krishnaswamy G, Beaty TH (1994) Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations. Science 264(5162):1152-156 CrossRef
  23. Postma DS, Bleecker ER, Amelung PJ, Holroyd KJ, Xu J, Panhuysen CI, Meyers DA, Levitt RC (1995) Genetic susceptibility to asthma–bronchial hyperresponsiveness coinherited with a major gene for atopy. N Engl J Med 333(14):894-00 CrossRef
  24. Venkayya R, Lam M, Willkom M, Grunig G, Corry DB, Erle DJ (2002) The Th2 lymphocyte products IL-4 and IL-13 rapidly induce airway hyperresponsiveness through direct effects on resident airway cells. Am J Respir Cell Mol Biol 26(2):202-08 CrossRef
  25. Dabbagh K, Takeyama K, Lee HM, Ueki IF, Lausier JA, Nadel JA (1999) IL-4 induces mucin gene expression and goblet cell metaplasia in vitro and in vivo. J Immunol 162(10):6233-237
  26. Whittaker L, Niu N, Temann UA, Stoddard A, Flavell RA, Ray A, Homer RJ, Cohn L (2002) Interleukin-13 mediates a fundamental pathway for airway epithelial mucus induced by CD4 T cells and interleukin-9. Am J Respir Cell Mol Biol 27(5):593-02 CrossRef
  27. Zheng T, Zhu Z, Wang Z, Homer RJ, Ma B, Riese RJ Jr, Chapman HA Jr, Shapiro SD, Elias JA (2000) Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J Clin Invest 106(9):1081-093 CrossRef
  28. Graves PE, Kabesch M, Halonen M, Holberg CJ, Baldini M, Fritzsch C, Weiland SK, Erickson RP, von Mutius E, Martinez FD (2000) A cluster of seven tightly linked polymorphisms in the IL-13 gene is associated with total serum IgE levels in three populations of white children. J Allergy Clin Immunol 105(3):506-13 CrossRef
  29. Leung TF, Tang NL, Chan IH, Li AM, Ha G, Lam CW (2001) A polymorphism in the coding region of interleukin-13 gene is associated with atopy but not asthma in Chinese children. Clin Exp Allergy 31(10):1515-521 CrossRef
  30. Wang M, Xing ZM, Lu C, Ma YX, Yu DL, Yan Z, Wang SW, Yu LS (2003) A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis. Hum Genet 113(5):387-90 CrossRef
  31. Maier LM, Howson JM, Walker N, Spickett GP, Jones RW, Ring SM, McArdle WL, Lowe CE, Bailey R, Payne F, Todd JA, Strachan DP (2006) Association of IL13 with total IgE: evidence against an inverse association of atopy and diabetes. J Allergy Clin Immunol 117(6):1306-313 CrossRef
  32. Chan IH, Leung TF, Tang NL, Li CY, Sung YM, Wong GW, Wong CK, Lam CW (2006) Gene–gene interactions for asthma and plasma total IgE concentration in Chinese children. J Allergy Clin Immunol 117(1):127-33 CrossRef
  33. Heinzmann A, Mao XQ, Akaiwa M, Kreomer RT, Gao PS, Ohshima K, Umeshita R, Abe Y, Braun S, Yamashita T, Roberts MH, Sugimoto R, Arima K, Arinobu Y, Yu B, Kruse S, Enomoto T, Dake Y, Kawai M, Shimazu S, Sasaki S, Adra CN, Kitaichi M, Inoue H, Yamauchi K, Tomichi N, Kurimoto F, Hamasaki N, Hopkin JM, Izuhara K, Shirakawa T, Deichmann KA (2000) Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 9(4):549-59 CrossRef
  34. Howard TD, Whittaker PA, Zaiman AL, Koppelman GH, Xu J, Hanley MT, Meyers DA, Postma DS, Bleecker ER (2001) Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol 25(3):377-84 CrossRef
  35. van der Pouw Kraan TC, Kucukaycan M, Bakker AM, Baggen JM, van der Zee JS, Dentener MA, Wouters EF, Verweij CL (2002) Chronic obstructive pulmonary disease is associated with the ?055 IL-13 promoter polymorphism. Genes Immun 3(7):436-39 CrossRef
  36. Hegab AE, Sakamoto T, Saitoh W, Massoud HH, Massoud HM, Hassanein KM, Sekizawa K (2004) Polymorphisms of IL4, IL13, and ADRB2 genes in COPD. Chest 126(6):1832-839 CrossRef
  37. Beghe B, Hall IP, Parker SG, Moffatt MF, Wardlaw A, Connolly MJ, Fabbri LM, Ruse C, Sayers I (2010) Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease. Allergy 65(4):474-81 CrossRef
  38. Guo Y, Gong Y, Pan C, Qian Y, Shi G, Cheng Q, Li Q, Ren L, Weng Q, Chen Y, Cheng T, Fan L, Jiang Z, Wan H (2012) Association of genetic polymorphisms with chronic obstructive pulmonary disease in the Chinese Han population: a case-control study. BMC Med Genomics 5:64 CrossRef
  39. Huedo-Medina TB, Sanchez-Meca J, Marin-Martinez F, Botella J (2006) Assessing heterogeneity in meta-analysis: Q statistic or I2 index? Psychol Methods 11(2):193-06 CrossRef
  40. Harbord RM, Egger M, Sterne JA (2006) A modified test for small-study effects in meta-analyses of controlled trials with binary endpoints. Stat Med 25(20):3443-457 CrossRef
  41. Wei W, Yajuan Y, Ran Q, Wuxuan M, Cuiping H (2011) IL-13, IL-4 and β2-adrenergic receptor gene polymorphisms association with chronic obstructive pulmonary disease. J Clin Inter Med 28(5):332-34 (in Chinese)
  42. Grunig G, Warnock M, Wakil AE, Venkayya R, Brombacher F, Rennick DM, Sheppard D, Mohrs M, Donaldson DD, Locksley RM, Corry DB (1998) Requirement for IL-13 independently of IL-4 in experimental asthma. Science 282(5397):2261-263 CrossRef
  43. Wills-Karp M, Luyimbazi J, Xu X, Schofield B, Neben TY, Karp CL, Donaldson DD (1998) Interleukin-13: central mediator of allergic asthma. Science 282(5397):2258-261 CrossRef
  44. Vestbo J, Prescott E, Lange P (1996) Association of chronic mucus hypersecretion with FEV1 decline and chronic obstructive pulmonary disease morbidity. Copenhagen City Heart Study Group. Am J Respir Crit Care Med 153(5):1530-535
  45. Prescott E, Lange P, Vestbo J (1995) Chronic mucus hypersecretion in COPD and death from pulmonary infection. Eur Respir J 8(8):1333-338 CrossRef
  46. Famuyiwa F, Rubinstein I (2012) Chronic sinopulmonary inflammatory diseases in adults with undetectable serum IgE in inner-city Chicago: a preliminary observation. Lung 190(3):291-94 CrossRef
  
• 作者单位：Lian Duan (1)
  Rui Liang (2)
  Zhendong Wang (1)
  Lei Lei (1) (3)
  Lianhong Jin (1) (3)
  Jingling Shen (1) (3)
  Shoude Jin (2)
  
  1. Department of Histology and Embryology, Harbin Medical University, 194 Xuefu Road, Nangang District, Harbin, Heilongjiang, China
  2. Division of Respiratory Disease, The Fourth Affiliated Hospital of Harbin Medical University, 37 Yiyuan Street, Nangang District, Harbin, Heilongjiang, China
  3. Embryo and Stem Cell Engineering Laboratory, Harbin Medical University, Harbin, China
  
• ISSN：1573-4978

文摘

Numerous studies have investigated association of interleukin-13 (IL-13) G+2044A polymorphism with COPD susceptibility; however, the results were inconsistent and inconclusive. To evaluate the association between the IL-13 G+2044A polymorphism and susceptibility to COPD, a meta-analysis of published case–control studies was performed. Based on PubMed and Chinese database, this research selected studies that examined the association of the IL-13 G+2044A polymorphism with COPD. A genetic model-free approach was used to assess whether the combined data showed this association. Then a subgroup analysis was also performed, with stratifications for race, study design, and sample size. Six studies (total 1,213 COPD patients and 801 control subjects) for the IL-13 G+2044A polymorphism with COPD were included in the meta-analysis (G- vs A-allele: OR 1.12, 95?% CI 0.96-.32, P?=?0.15; genotypes GG+GA vs genotype AA: OR 0.99, 95?% CI 0.49-.00, P?=?0.98; genotype GG vs genotypes GA+AA: OR 1.18, 95?% CI 0.97-.44, P?=?0.09; genotype GA vs genotypes GG+AA: OR 0.85, 95?% CI 0.70-.04, P?=?0.11). This meta-analysis demonstrates that the IL-13 G+2044A polymorphism does not confer susceptibility to COPD. More detailed data about individual and environment, larger sample sizes with unbiased genotyping methods and matched controls in different populations are required.