NIR- and UV-dual responsive amphiphilic copolymer micelles with light-dissociable PAG-side groups
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- 作者：Youpeng Wang ; Guo Li ; Ruidong Cheng ; Xuan Zhang…
- 关键词：Amphiphilic copolymer ; Upconverting nanoparticle ; Micelle ; Photoacid generator
- 刊名：Colloid and Polymer Science
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：295
- 期：2
- 页码：371-378
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Polymer Sciences; Soft and Granular Matter, Complex Fluids and Microfluidics; Characterization and Evaluation of Materials; Physical Chemistry; Food Science; Nanotechnology and Microengineering;
- 出版者：Springer Berlin Heidelberg
- ISSN：1435-1536
- 卷排序：295
文摘
Amphiphilic random copolymer micelle of P(NVP-co-NHPM) that responds to both UV and NIR light was designed and investigated. N-hydroxyphthalimide methacrylate—bearing a photoacid generator functional group was synthesized and used to construct the hydrophobic segment of P(NVP-co-NHPM); the N–O bond can be photocleaved when exposing the polymer aqueous solution to 310 nm UV light irradiation, inducing the micellar dissociation and delivery of loaded substances. Dynamic light scattering (DLS), atomic force microscope (AFM), and transmission electron microscopy (TEM) were used to characterize the micellar dissociation and controlled release processes. Moreover, the upconverting nanoparticles (NaLuF4:Gd/Yb/Tm) that can effectively absorb NIR light and convert it into visible and UV light were coloaded into polymer micelles to activate the micellar dissociation and the delivery of loaded cargoes via 980 nm NIR light.