Effects and Mechanism of Action of Ligustrazine on Isoprenaline-Induced Cardiomyocyte Hypertrophy
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- 作者：Xuan Xiu Ji (1)
Xiao Li Song (2)
Wei Qian (1)
Xiao Lin Yu (1)
Jian You Zhu (1) - 关键词：Ligustrazine ; Isoprenaline ; Cardiomyocyte hypertrophy ; Effect ; Mechanism
- 刊名：Cell Biochemistry and Biophysics
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：70
- 期：3
- 页码：1513-1518
- 全文大小：448 KB
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Xiao Li Song (2)
Wei Qian (1)
Xiao Lin Yu (1)
Jian You Zhu (1)
1. Second Department of Geriatric Division, General Hospital of Jinan Military Region, Jinan, 250031, China
2. Department of Pharmacology, School of Basic Medical College of Shandong University of Traditional Chinese Medicine, University Science Park, Changqing District, Jinan, 250355, China - ISSN：1559-0283
文摘
The aim of the study is to explore the effects and mechanism of the action of ligustrazine on isoprenaline-induced cardiomyocyte hypertrophy. Primary culture of neonatal rat cardiomyocytes was used as the model, and isoprenaline was used to induce cardiomyocyte hypertrophy. Effects of different dosages of ligustrazine polysaccharide on the cardiomyocyte were observed. RT-PCR was used to detect the expression of atrial natriuretic factor (ANP) mRNA, and Western blot analysis was used to detect the CaN protein level in cardiomyocytes. After treating with ligustrazine, the significant increase of MDA content and decrease of SOD activity were inhibited in supernatant. Compared to the control group, ANP mRNA in isoprenaline-treated cardiomyocytes was significantly increased (P?mRNA was significantly decreased in all ligustrazine groups (P?