A Fully Automatic HPLC–CAD–DAD Method Coupled with ASE and Online SPE for Simultaneous Determination of Seven Antibiotics in Bio-Matrices

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• 作者：Qian Zhou ; Nan Wang ; Lihua Zhu ; Heqing Tang
• 关键词：Column liquid chromatography ; Online SPE ; Multi ; component analysis ; Antibiotics ; Bio ; matrices ; Accelerated solvent extraction
• 刊名：Chromatographia
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：78
• 期：23-24
• 页码：1475-1484
• 全文大小：1,040 KB
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• 作者单位：Qian Zhou (1)
  Nan Wang (1)
  Lihua Zhu (1)
  Heqing Tang (2)
  
  1. College of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, 430074, People’s Republic of China
  2. Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission and Ministry of Education, College of Resources and Environmental Science, South-Central University for Nationalities, Wuhan, 430074, People’s Republic of China
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Organic Chemistry
  Pharmacy
  Biochemistry
  Plant Sciences
  Measurement Science and Instrumentation
  
• 出版者：Vieweg Verlag
• ISSN：1612-1112

文摘

It is a challenge to simultaneously determine the multiple-component targets in complex matrices when some of the targets bear chromophores but some contain no chromophores. A novel HPLC–CAD–DAD method coupled with accelerated solvent extraction and online solid phase extraction (SPE) was developed for simultaneous determination of seven antibiotics in solid bio-matrices. The online SPE operation parameters were optimized on a Acclaim?120 C18 cartridge in terms of extraction efficiency with sample injection volume of 1 mL, and the online SPE operation yielded enhancement factors in the range of 29-7 for the different antibiotics. The proposed method showed good recoveries ranging between 79.2 and 104.7 % for different antibiotics and excellent inter-day and intra-day precision with relative standard deviation values ranging from 0.6 to 7.8 %. The detection limits were between 1.8 and 18.0 μg kg?. Keywords Column liquid chromatography Online SPE Multi-component analysis Antibiotics Bio-matrices Accelerated solvent extraction