参考文献:Ahn JY (2014) Neuroprotection signaling of nuclear akt in neuronal cells. Exp Neurobiol 23:200–206PubMedCentral CrossRef PubMed Beaulieu JM, Caron MG (2008) Looking at lithium: molecular moods and complex behaviour. Mol Interv 8:230–241CrossRef PubMed Beaulieu JM, Marion S, Rodriguiz RM, Medvedev IO, Sotnikova TD, Ghisi V, Wetsel WC, Lefkowitz RJ, Gainetdinov RR, Caron MG (2008) A beta-arrestin 2 signaling complex mediates lithium action on behavior. Cell 132:125–136CrossRef PubMed Beaulieu JM, Gainetdinov RR, Caron MG (2009) Akt/GSK3 signaling in the action of psychotropic drugs. Annu Rev Pharmacol Toxicol 49:327–347CrossRef PubMed Bowden CL (2000) Efficacy of lithium in mania and maintenance therapy of bipolar disorder. J Clin Psychiatry 61(Suppl 9):35–40PubMed Bschor T, Bauer M (2013) Side effects and risk profile of lithium: critical assessment of a systematic review and meta-analysis. Nervenarzt 84:860–863CrossRef PubMed Chalecka-Franaszek E, Chuang DM (1999) Lithium activates the serine/threonine kinase Akt-1 and suppresses glutamate-induced inhibition of Akt-1 activity in neurons. Proc Natl Acad Sci U S A 96:8745–8750PubMedCentral CrossRef PubMed Chuang DM (2005) The antiapoptotic actions of mood stabilizers: molecular mechanisms and therapeutic potentials. Ann N Y Acad Sci 1053:195–204CrossRef PubMed Curran G, Ravindran A (2014) Lithium for bipolar disorder: a review of the recent literature. Expert Rev Neurother 14:1079–1098CrossRef PubMed De Sarno P, Li X, Jope RS (2002) Regulation of Akt and glycogen synthase kinase-3 beta phosphorylation by sodium valproate and lithium. Neuropharmacology 43:1158–1164CrossRef PubMed Franke TF, Kaplan DR, Cantley LC (1997) PI3K: downstream AKTion blocks apoptosis. Cell 88:435–437CrossRef PubMed Freland L, Beaulieu JM (2012) Inhibition of GSK3 by lithium, from single molecules to signaling networks. Front Mol Neurosci 5:14PubMedCentral CrossRef PubMed Galli G, Fratelli M (1993) Activation of apoptosis by serum deprivation in a teratocarcinoma cell line: inhibition by L-acetylcarnitine. Exp Cell Res 204:54–60CrossRef PubMed Gan L, Zheng W, Chabot JG, Unterman TG, Quirion R (2005) Nuclear/cytoplasmic shuttling of the transcription factor FoxO1 is regulated by neurotrophic factors. J Neurochem 93:1209–1219CrossRef PubMed Gong X, Fan G, Wang W, Wang G (2014) Trimetazidine protects umbilical cord mesenchymal stem cells against hypoxia and serum deprivation induced apoptosis by activation of Akt. Cell Physiol Biochem Int J Exp Cell Physiol Biochem Pharmacol 34:2245–2255CrossRef Le Roy V, Delmas Y, Verdoux H (2009) Chronic renal complications induced by lithium. L’Encéphale 35:605–610CrossRef PubMed Levi A, Biocca S, Cattaneo A, Calissano P (1988) The mode of action of nerve growth factor in PC12 cells. Mol Neurobiol 2:201–226CrossRef PubMed Li Q, Chen M, Liu H, Yang L, Yang T, He G (2014) The dual role of ERK signaling in the apoptosis of neurons. Front Biosci 19:1411–1417CrossRef Lindenboim L, Diamond R, Rothenberg E, Stein R (1995) Apoptosis induced by serum deprivation of PC12 cells is not preceded by growth arrest and can occur at each phase of the cell cycle. Cancer Res 55:1242–1247PubMed Mao Z, Liu L, Zhang R, Li X (2007) Lithium reduces FoxO3a transcriptional activity by decreasing its intracellular content. Biol Psychiatry 62:1423–1430CrossRef PubMed Mora A, Gonzalez-Polo RA, Fuentes JM, Soler G, Centeno F (1999) Different mechanisms of protection against apoptosis by valproate and Li+. Eur J Biochem / FEBS 266:886–891CrossRef Pan JQ, Lewis MC, Ketterman JK, Clore EL, Riley M, Richards KR, Berry-Scott E, Liu X, Wagner FF, Holson EB, Neve RL, Biechele TL, Moon RT, Scolnick EM, Petryshen TL, Haggarty SJ (2011) AKT kinase activity is required for lithium to modulate mood-related behaviors in mice. Neuropsychopharmacol Off Publ Am Coll Neuropsychopharmacol 36:1397–1411CrossRef Polter A, Yang S, Zmijewska AA, van Groen T, Paik JH, Depinho RA, Peng SL, Jope RS, Li X (2009) Forkhead box, class O transcription factors in brain: regulation and behavioral manifestation. Biol Psychiatry 65:150–159PubMedCentral CrossRef PubMed Rowe MK, Chuang DM (2004) Lithium neuroprotection: molecular mechanisms and clinical implications. Expert Rev Mol Med 6:1–18CrossRef PubMed Shafaei-Bajestani N, Emami SA, Asili J, Tayarani-Najaran Z (2014) Anti-apoptotic effect of taxodione on serum/glucose deprivation-induced PC12 cells death. Cell Mol Neurobiol 34:1103–1109CrossRef PubMed Tzivion G, Dobson M, Ramakrishnan G (2011) FoxO transcription factors; Regulation by AKT and 14-3-3 proteins. Biochim Biophys Acta 1813:1938–1945CrossRef PubMed Wang R, Yang J, Peng L, Zhao J, Mu N, Huang J, Lazarovici P, Chen H, Zheng W (2015) Gardenamide A attenuated cell apoptosis induced by serum deprivation insult via the ERK1/2 and PI3K/AKT signaling pathways. Neuroscience 286:242–250CrossRef PubMed Weeks KR, Dwyer DS, Aamodt EJ (2011) Clozapine and lithium require Caenorhabditis elegans beta-arrestin and serum- and glucocorticoid-inducible kinase to affect Daf-16 (Foxo) localization. J Neurosci Res 89:1658–1665CrossRef PubMed Wen Q, Duan X, Liao R, Little P, Gao G, Jiang H, Lalit S, Quirion R, Zheng W (2011) Characterization of intracellular translocation of Forkhead transcription factor O (FoxO) members induced by NGF in PC12 cells. Neurosci Lett 498:31–36CrossRef PubMed Xia Y, Wang CZ, Liu J, Anastasio NC, Johnson KM (2008) Lithium protection of phencyclidine-induced neurotoxicity in developing brain: the role of phosphatidylinositol-3 kinase/Akt and mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathways. J Pharmacol Exp Ther 326:838–848PubMedCentral CrossRef PubMed Yang SD, Bai ZL, Zhang F, Ma L, Yang DL, Ding WY (2014) Levofloxacin increases the effect of serum deprivation on anoikis of rat nucleus pulposus cells via Bax/Bcl-2/caspase-3 pathway. Toxicol Mech Methods 24:688–696CrossRef PubMed Zhang X, Tang N, Hadden TJ, Rishi AK (2011) Akt, FoxO and regulation of apoptosis. Biochim Biophys Acta 1813:1978–1986CrossRef PubMed Zheng WH, Quirion R (2009) Glutamate acting on N-methyl-D-aspartate receptors attenuates insulin-like growth factor-1 receptor tyrosine phosphorylation and its survival signaling properties in rat hippocampal neurons. J Biol Chem 284:855–861CrossRef PubMed Zheng WH, Kar S, Dore S, Quirion R (2000a) Insulin-like growth factor-1 (IGF-1): a neuroprotective trophic factor acting via the Akt kinase pathway. J Neural Transm Suppl 261–272 Zheng WH, Kar S, Quirion R (2000b) Insulin-like growth factor-1-induced phosphorylation of the forkhead family transcription factor FKHRL1 is mediated by Akt kinase in PC12 cells. J Biol Chem 275:39152–39158CrossRef PubMed Zheng W, Wang H, Zeng Z, Lin J, Little PJ, Srivastava LK, Quirion R (2012) The possible role of the Akt signaling pathway in schizophrenia. Brain Res 1470:145–158CrossRef PubMed Zheng W, Zeng Z, Bhardwaj SK, Jamali S, Srivastava LK (2013) Lithium normalizes amphetamine-induced changes in striatal FoxO1 phosphorylation and behaviors in rats. Neuroreport 24:560–565CrossRef PubMed
作者单位:Zhiwen Zeng (1) (2) Haitao Wang (3) Fu Shang (3) Lihua Zhou (4) Peter J. Little (5) Remi Quirion (6) Wenhua Zheng (1)
1. Faculty of Health Science, University of Macau, Room 4021, Building E12, Avenida de Universidade Taipa, Macau, People’s Republic of China 2. Key Laboratory of Neurogenetics and Channelopathies of Guangdong Province and the Ministry of Education of China, Collaborative Innovation Center for Neurogenetics and Channelopathies, Institute of Neuroscience, The Second Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China 3. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center and Neurophamacology, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou, 510060, People’s Republic of China 4. Zhongshan Medical School, Sun Yat-Sen University, Guangzhou, 510060, People’s Republic of China 5. School of Pharmacy, Pharmacy Australia Centre of Excellence, The University of Queensland, 20 Cornwall St, Woolloongabba, QLD, 4102, Australia 6. Douglas Hospital Research Center, McGill University, Montreal, Canada
刊物类别:Biomedical and Life Sciences
刊物主题:Biomedicine Pharmacology and Toxicology Psychiatry
出版者:Springer Berlin / Heidelberg
ISSN:1432-2072
文摘
Rationale Lithium is currently used in the treatment of mental illness. We have previously reported that lithium stimulated the protein kinase B/Forkhead box O1 (Akt/FoxO1) pathway in rats. However, little information is available regarding its neuroprotective role of this pathway and underlying mechanisms.