Biosynthesis and biotechnological production of anti-cancer drug Camptothecin

详细信息    查看全文

• 作者：Guoyin Kai ; Chao Wu ; Liyuan Gen ; Liqiang Zhang ; Lijie Cui…
• 关键词：Biosynthesis ; Camptothecin ; Endophytes ; Gene cloning ; Hairy root ; Metabolic engineering
• 刊名：Phytochemistry Reviews
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：14
• 期：3
• 页码：525-539
• 全文大小：796 KB
• 参考文献：Aimi N, Nishimura M, Miwa A, Hoshino H, Sakai S, Haginiwa J (1989) Pumiloside and deoxypumiloside; plausible intermediates of camptothecin biosynthesis. Tetrahedron Lett 30:4991-994View Article
  Amna T, Puri SC, Verma V, Sharma JP, Khajuria RK, Musarrat J, Spiteller M, Qazi GN (2006) Bioreactor studies on the endophytic fungus Entrophospora infrequens for the production of an anticancer alkaloid camptothecin. Can J Microbiol 52(3):189-96View Article PubMed
  Arisawa M, Gunasekera SP, Cordell GA, Farnsworth NR (1981) Plant anticancer agents XXI constituents of Merrilliodendron megacarpum. Planta Med 43:404-07View Article PubMed
  Asano T, Watase I, Sudo H, Kitajima M, Takayama H, Aimi N, Yamazaki M, Saito K (2004) Camptothecin production by in vitro cultures of Ophiorrhiza liukiuensis and O. kuroiwai. Plant Biotechnol 21(4):275-81View Article
  Asano T, Kobayashi K, Kashihara E, Sudo H, Sasaki R, Iijima Y, Aoki K, Shibata D, Saito K, Yamazaki M (2013) Suppression of camptothecin biosynthetic genes results in metabolic modification of secondary products in hairy roots of Ophiorrhiza pumila. Phytochemistry 91:128-39View Article PubMed
  Aule O, Furholz A, Chang HS, Zhu T, Wang X, Heifetz PB, Gruissem W, Markus LB (2003) Crosstalk between cytosolic and plastidial pathways of isoprenoid biosynthesis in Arabidopsis thaliana. Proc Natl Acad Sci USA 100:6866-871View Article
  Beegum AS, Martin KP, Zhang CL, Nishitha IK, Ligimol SA, Madhusoodanan PV (2007) Organogenesis from leaf and internode explants of Ophiorrhiza prostrata, an anticancer drug (camptothecin) producing plant. Electronic J Biotechnol 10(1):114-23View Article
  Burnett RT, Maldonado-Mendoza IE, Mcknight TD, Nessler CL (1993) Expression of a 3-hydroxy-3-methylglutaryl coenzyme a reductase cene from Camptotheca acuminata is differentially regulated by wounding and methyl jasmonate. Plant Physiol 103:41-8View Article PubMed Central PubMed
  Canel C, Lopes-Cardoso MI, Whitmer S (1998) Effects of overexpression of strictosidine synthase and tryptophan decarboxylase on alkaloid production by cell cultures of Catharanthus roseus. Planta 205:414-19View Article PubMed
  Chandra S (2012) Endophytic fungi: novel sources of anticancer lead molecules. Appl Microbiol Biotechnol 95(1):47-9View Article PubMed
  Collu G, Alonso-García A, van Der Heijden R, Verpoorte R (2002) Activity of the cytochrome P450 enzyme geraniol-10-hydroxylase and alkaloid production in plant cell cultures. Plant Sci 162:165-72View Article
  Crawford IP (1989) Evolution of a biosynthetic pathway: the tryptophan paradigm. Annu Rev Microbiol 43:567-00View Article PubMed
  Cui LJ, Ni XL, Ji Q, Teng XJ, Yang YR, Wu C, Zekria D, Zhang DS, Kai GY (2015) Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila. Sci Rep 5:8227View Article PubMed Central PubMed
  De Luca V, Marineau C, Brisson N (1989) Molecular cloning and analysis of a cDNA encoding a plant tryptophan decarboxylase: comparison with animal DOPA decarboxylases. Proc Natl Acad Sci USA 86:2582-586View Article PubMed Central PubMed
  Ding X, Liu K, Deng B, Chen W, Li W, Liu F (2013) Isolation and characterization of endophytic fungi from Camptotheca acuminata. World J Microbiol Biotechnol 29(10):1831-838
  Fujimoto T, Tomitaka Y, Abe H, Tsuda S, Futai K, Mizukubo T (2011) Expression profile of jasmonic acid-induced genes and the induced resistance against the root-knot nematode (Meloidogyne incognita) in tomato plants (Solanum lycopersicum) after foliar treatment with methyl jasmonate. J Plant Physiol 168(10):1084-097
  Fulzele DP, Satdive RK (2005) Comparison of techniques for the extraction of the anti-cancer drug camptothecin from Nothapodytes foetida. J Chromatogr A 1063(1-):9-3View Article PubMed
  Georgiev M, Agostini E, Ludwig-Müller J, Xu J (2012) Genetically transformed roots: from plant disease to biotechnology. Trends Biotechnol 30:528-37View Article PubMed
  Govindachari TR, Viswanathan N (1972) Alkaloids of Mappia foetida. Phytochemistry 11:3529-531View Article
  Gu Q, Song DF, Zhang H, Zhu MY (2006) Effects of Cu2+ on biosynthesis of camptothecin in cell cultures of Camptotheca acuminata. Sheng Wu Gong Cheng Xue Bao 22(4):624-28PubMed
  Gunasekera SP, Badawi MM, Cordell GA, Farnsworth NR, Chitnis M (1979) Plant anticancer agents X. Isolation of camptothecin and 9-methoxycamptothecin from Ervatamia heyneana. J Nat Prod 42:475-77View Article PubMed
  Gurudatt PS, Priti V, Shweta S, Ramesha BT, Ravikanth G, Vasudeva R, Amna T, Deepika S, Ganeshaiah KN, Shaanker RU, Puri S, Qazi GN (2010) Attenuation of camptothecin production and negative relation between hyphal biomass and camptothecin content in endophytic fungal strains isolated from Nothapodytes nimmoniana Grahm (Icacinaceae). Curr Sci 98:1006-010
  Hao XL, Shi M, Cui LJ, Xu C, Zhang YJ, Kai GY (2015) Effects of methyl
• 作者单位：Guoyin Kai (1)
  Chao Wu (1)
  Liyuan Gen (1)
  Liqiang Zhang (1)
  Lijie Cui (1)
  Xiaoling Ni (2)
  
  1. Laboratory of Plant Biotechnology, Development Center of Plant Germplasm Resources, College of Life and Environment Sciences, Shanghai Normal University, Shanghai, 200234, China
  2. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, 200032, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Plant Sciences
  Biochemistry
  Organic Chemistry
  Chemistry
  
• 出版者：Springer Netherlands
• ISSN：1572-980X

文摘

Camptothecin (CPT) is a kind of modified monoterpene indole alkaloid firstly identified from woody plant Camptotheca acuminata, and its semisynthetic CPT analogs irinothecan and topothecan are clinically used for the treatment of various cancers throughout the world. However, the extraction of CPT from limited natural CPT-producing plant resources couldn’t meet the rapidly increasing market need. The development of plant metabolic engineering provides one alternative way to increase CPT yield by genetic manipulation, which relies on in-depth understanding of the CPT biosynthesis pathway. Several attempts have been also made to obtain CPT by biotechnological approaches such as cell suspensions, endophytic fungi, hairy roots, elicitation as well as metabolic engineering in the past decade. Here, recent advances in knowledge of biosynthesis of CPT, gene isolation, molecular regulation, production improvement and biotechnological methods are summarized and future perspectives are also discussed in this review.