Phase I study of LY2181308, an antisense oligonucleotide against survivin, in patients with advanced solid tumors
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- 作者：1. Division of Internal Medicine ; National Cancer Center Hospital ; 5-1-1 Tsukiji ; Chuo-ku ; Tokyo ; 104-0045 Japan2. Eli Lilly Japan K.K. ; Sannomiya Plaza Bldg. ; 7-1-5 ; Isogamidori ; Chuo-ku ; Kobe ; 651-0086 Japan3. Eli Lilly and Company ; Erl Wood Manor ; Windlesham ; Surrey ; GU20 6PH UK
- 关键词：Antisense oligonucleotide – ; Pharmacokinetics – ; Phase I – ; Survivin
- 刊名：Cancer Chemotherapy and Pharmacology
- 出版年：2011
- 出版时间：August 2011
- 年：2011
- 卷：68
- 期：2
- 页码：505-511
- 全文大小：375.0 KB
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22. Nokihara H, Yamamoto N, Yamada Y, Yamada K, Goto Y, Tanioka M, Nambu Y, Uenaka K, Sekiguchi R, Tamura T (2009) A phase 1 study of an antisense oligonucleotide against survivin (LY2181308) in Japanese patients with solid tumors. Mol Cancer Ther 8:B48. doi:10.1158/1535-7163.TARG-09-B48 - 作者单位：http://www.springerlink.com/content/j03660pw48741645/
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine
Cancer Research
Pharmacology and Toxicology
Oncology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-0843
文摘
Purpose LY2181308 is an antisense oligonucleotide that complementarily binds to survivin mRNA and inhibits its expression in tumor tissue. This phase I dose escalation study evaluated the tolerability, pharmacokinetics, and anticancer activity of LY2181308 in Japanese.