Evolutionary analysis across mammals reveals distinct classes of long non-coding RNAs

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• 作者：Jenny Chen ; Alexander A. Shishkin ; Xiaopeng Zhu ; Sabah Kadri ; Itay Maza…
• 关键词：Long non ; coding RNAs ; Evolution ; Comparative genomics ; Molecular evolution ; Annotation ; LincRNA ; RNA ; seq ; Transcriptome
• 刊名：Genome Biology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：1,019 KB
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• 作者单位：Jenny Chen (1) (2)
  Alexander A. Shishkin (3)
  Xiaopeng Zhu (4)
  Sabah Kadri (1)
  Itay Maza (5)
  Mitchell Guttman (3)
  Jacob H. Hanna (5)
  Aviv Regev (1) (6)
  Manuel Garber (4) (7)
  
  1. Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA
  2. Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, MA, 02140, USA
  3. Division of Biology and Biological Engineering, California Institute of Technology, Cambridge, MA, 02140, USA
  4. Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA, 01655, USA
  5. Department of Molecular Genetics, Weizmann Institute of Science, Rehovot, 76100, Israel
  6. Howard Hughes Medical Institute, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, 02140, USA
  7. Program in Molecular Biology, University of Massachusetts Medical School, Worcester, MA, 01655, USA
  
• 刊物主题：Animal Genetics and Genomics; Human Genetics; Plant Genetics & Genomics; Microbial Genetics and Genomics; Fungus Genetics; Bioinformatics;
• 出版者：BioMed Central
• ISSN：1465-6906

文摘

Background Recent advances in transcriptome sequencing have enabled the discovery of thousands of long non-coding RNAs (lncRNAs) across many species. Though several lncRNAs have been shown to play important roles in diverse biological processes, the functions and mechanisms of most lncRNAs remain unknown. Two significant obstacles lie between transcriptome sequencing and functional characterization of lncRNAs: identifying truly non-coding genes from de novo reconstructed transcriptomes, and prioritizing the hundreds of resulting putative lncRNAs for downstream experimental interrogation.