TRIM28 as an independent prognostic marker plays critical roles in glioma progression

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• 作者：Zeng-Xin Qi ; Jia-Jun Cai ; Ling-Chao Chen ; Qi Yue ; Yan Gong…
• 关键词：TRIM28 ; Gliomas ; Proliferation ; Prognosis ; Malignancy
• 刊名：Journal of Neuro-Oncology
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：126
• 期：1
• 页码：19-26
• 全文大小：2,701 KB
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• 作者单位：Zeng-Xin Qi (1)
  Jia-Jun Cai (1)
  Ling-Chao Chen (1)
  Qi Yue (1)
  Yan Gong (2)
  Yu Yao (1)
  Ying Mao (1) (3)
  
  1. Department of Neurosurgery, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China
  2. Department of Geriatrics, Huashan Hospital, Fudan University, 12 Wulumuqi Middle Road, Shanghai, 200040, China
  3. State Key Laboratory of Medical Neurobiology, Institutes of Biomedical Sciences, Fudan University, Shanghai, 200032, China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7373

文摘

Tripartite motif (TRIM) proteins are involved in tumorigenesis. Here, we examined the expression, biological function, and clinical significance of tripartite motif containing 28 (TRIM28) in glioma, a locally aggressive brain tumor. First, TRIM28 expression was significantly higher in glioma (n = 138) than in non-glioma controls (n = 6). TRIM28 expression was positively correlated with tumor malignancy, and associated with poor overall survival (OS) and progression-free survival (PFS). Notably, TRIM28 expression was negatively correlated with p21 expression in patients with glioblastoma multiforme (GBM). A multivariate analysis that included relevant measures indicated that high TRIM28 expression is an independent prognostic factor for poor OS and PFS in GBM patients. In experiments with cultured glioma cells, down-regulating TRIM28 with shRNA increased p21 expression, and induced cell cycle arrest at the G1 phase. In a xenograft model, down-regulating TRIM28 suppressed tumor growth. These results indicate that over-expression of TRIM28 is associated with poor outcome in glioma patients. Keywords TRIM28 Gliomas Proliferation Prognosis Malignancy