What caused the changes in the usage of Atractylodis Macrocephalae Rhizoma from ancient to current times?

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• 作者：Xiaotong Wang ; Linghui Li ; Xiaoku Ran ; Deqiang Dou ; Bin Li…
• 关键词：Atractylodis Macrocephala Rhizoma ; Atractylodes macrocephala Koidz ; Traditional medicine ; Expectorant ; Tocolysis ; Volatile oil
• 刊名：Journal of Natural Medicines
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：70
• 期：1
• 页码：36-44
• 全文大小：1,453 KB
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• 作者单位：Xiaotong Wang (1)
  Linghui Li (1)
  Xiaoku Ran (1)
  Deqiang Dou (1)
  Bin Li (1)
  Bingyou Yang (2)
  Wei Li (3)
  Kazuo Koike (3)
  Haixue Kuang (2)
  
  1. College of Pharmacy, Liaoning University of Traditional Chinese Medicine, Dalian, 116600, China
  2. College of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, China
  3. Faculty of Pharmaceutical Sciences, Toho University, Miyama 2-2-1, Funabashi, Chiba, 274-8510, Japan
  
• 刊物主题：Pharmacology/Toxicology; Plant Sciences; Complementary & Alternative Medicine; Medicinal Chemistry; Pharmacy;
• 出版者：Springer Japan
• ISSN：1861-0293

文摘

Ancient Chinese medicine treatises on Atractylodis Macrocephalae Rhizoma (AMR), the rhizome of Atractylodes macrocephala Koidz, indicated that it possessed an expectorant effect. However, in modern times, it is commonly used as a tocolytic agent. In this study, the components of AMR that are responsible for its expectorant and tocolytic effects were evaluated in order to clarify the differences in its application between ancient and modern times. A decoction of AMR was separated into five fractions, namely, volatile oil (VO), petroleum ether (PE), alcohol eluate from macroporous resin (AE), water eluate from macroporous resin (WE), and polysaccharides (PS), using various separation methods. The expectorant experiment indicated that the VO fraction, which mainly contains atractylone, produced an obvious expectorant effect. The experiment that assessed the irritability of uterine smooth muscle (USM) showed that the PE, which is mainly composed of atractylenolides, and the PS, which is mainly composed of inulin-type polysaccharides, were the active fractions for tocolysis, but the VO fraction had the opposite action. These data suggested that volatile oils are the key components responsible for the usage change of AMR in both ancient and current usage. Keywords Atractylodis Macrocephala Rhizoma Atractylodes macrocephala Koidz Traditional medicine Expectorant Tocolysis Volatile oil