DCLK1 is up-regulated and associated with metastasis and prognosis in colorectal cancer
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- 作者：Tianbo Gao ; Min Wang ; Lingling Xu ; Tao Wen…
- 关键词：DCLK1 ; Colorectal cancer ; Metastasis ; Prognosis ; Epithelial–mesenchymal transition
- 刊名：Journal of Cancer Research and Clinical Oncology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：142
- 期：10
- 页码：2131-2140
- 全文大小：4,730 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Oncology
Cancer Research
Internal Medicine
Hematology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1335
- 卷排序：142
文摘
PurposeMetastasis is a primary cause of colorectal cancer (CRC)-related death, and cancer stem cells (CSCs) are thought to be majorly responsible for initiating metastatic behaviors. Doublecortin-like kinase 1 (DCLK1) was recently discovered to be a marker for gastrointestinal CSCs. Here, we aimed to explore whether DCLK1 is associated with CRC metastasis through clinical and in vitro investigations.