Aptamers Selected by Cell-SELEX for Molecular Imaging

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• 作者：Cheng Jin ; Jing Zheng ; Chunmei Li ; Liping Qiu…
• 关键词：Aptamer ; SELEX ; Molecular imaging ; Cancer ; Targeting ligands
• 刊名：Journal of Molecular Evolution
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：81
• 期：5-6
• 页码：162-171
• 全文大小：1,251 KB
• 参考文献：Barnes WL, Dereux A, Ebbesen TW (2003) Surface plasmon subwavelength optics. Nature 424:824CrossRef PubMed
  Bruchez M Jr, Moronne M, Gin P, Weiss S, Alivisatos AP (1998) Semiconductor nanocrystals as fluorescent biological labels. Science (New York, N.Y.) 281:2013CrossRef
  Cai W, Niu G, Chen X (2008) Imaging of Integrins as Biomarkers for Tumor Angiogenesis. Curr Pharm Des 14:2943CrossRef PubMed
  Chatteriee DK, Rufalhah AJ, Zhang Y (2008) Upconversion fluorescence imaging of cells and small animals using lanthanide doped nanocrystals. Biomaterials 29:937CrossRef
  Chen X, Estevez MC, Zhu Z, Huang Y-F, Chen Y, Wang L, Tan W (2009) Using aptamer-conjugated fluorescence resonance energy transfer nanoparticles for multiplexed cancer cell monitoring. Anal Chem 81:7009CrossRef PubMed
  Chen T, Shukoor MI, Wang R, Zhao Z, Yuan Q, Bamrungsap S, Xiong X, Tan W (2011) Smart multifunctional nanostructure for targeted cancer chemotherapy and magnetic resonance imaging. ACS Nano 5:7866PubMedCentral CrossRef PubMed
  Daniel MC, Astruc D (2004) Gold nanoparticles: assembly, supramolecular chemistry, quantum-size-related properties, and applications toward biology, catalysis, and nanotechnology. Chem Rev 104:293CrossRef PubMed
  Daniels DA, Chen H, Hicke BJ, Swiderek KM, Gold L (2003) A tenascin-C aptamer identified by tumor cell SELEX: systematic evolution of ligands by exponential enrichment. Proc Natl Acad Sci USA 100:15416PubMedCentral CrossRef PubMed
  Elghanian R, Storhoff JJ, Mucic RC, Letsinger RL, Mirkin CA (1997) Selective colorimetric detection of polynucleotides based on the distance-dependent optical properties of gold nanoparticles. Science (New York, N.Y.) 277:1078CrossRef
  Ellington AD, Szostak JW (1990) In vitro selection of RNA molecules that bind specific ligands. Nature 346:818CrossRef PubMed
  Estevez MC, O鈥橠onoghue MB, Chen X, Tan W (2009) Highly fluorescent dye-doped silica nanoparticles increase flow cytometry sensitivity for cancer cell monitoring. Nano Res 2:448CrossRef
  Fang X, Tan W (2010) Aptamers generated from Cell-SELEX for molecular medicine: a chemical biology approach. Acc Chem Res 43:48PubMedCentral CrossRef PubMed
  Fang X, Tan W (2015) Aptamers selected by cell-SELEX for theranostics. Anticancer Res 35:4380
  Guizhi Z, Shengfeng Z, Erqun S, Jing Z, Rong H, Xiaohong F, Weihong T (2013) Building fluorescent DNA nanodevices on target living cell surfaces. Angew Chem Int Ed 52:5490CrossRef
  Hayakawa Y, Wakabayashi S, Kato H, Noyori R (1990) The allylic protection method in solid-phase oligonucleotide synthesis-an efficient preparation of solid-anchored DNA oligomers. J Am Chem Soc 112:1691CrossRef
  Hong H, Goel S, Zhang Y, Cai W (2011) Molecular imaging with nucleic acid aptamers. Curr Med Chem 18:4195PubMedCentral CrossRef PubMed
  Hu M, Zhang K (2013) The application of aptamers in cancer research: an up-to-date review. Futur Oncol 9:369CrossRef
  Hu R, Zhang X, Zhao Z, Zhu G, Chen T, Fu T, Tan W (2014) DNA nanoflowers for multiplexed cellular imaging and traceable targeted drug delivery. Angew Chem Int Ed 53:5821CrossRef
  Huang Y-F, Chang H-T, Tan W (2008) Cancer cell targeting using multiple aptamers conjugated on nanorods. Anal Chem 80:567CrossRef PubMed
  Hui S, Xiaoxiao H, Kemin W, Xu W, Xiaosheng Y, Qiuping G, Weihong T, Zhihe Q, Xiaohai Y, Bing Z (2011) Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration. Proc Natl Acad Sci USA 108:3900CrossRef
  Jie G, Zhao Y, Qin Y (2014) A fluorescent polymeric quantum dot/aptamer superstructure and its application for imaging of cancer cells. Chemistry 9:1261
  Jinjin Y, Xiaoxiao H, Kemin W, Zhihe Q, Xu W, Hui S, Xiaohai Y (2012) One-step engineering of silver nanoclusters-aptamer assemblies as luminescent labels to target tumor cells. Nanoscale 4:110CrossRef
  Kaufmann BA, Lindner JR (2007) Molecular imaging with targeted contrast ultrasound. Curr Opin Biotechnol 18:11CrossRef PubMed
  Ke G, Wang C, Ge Y, Zheng N, Zhu Z, Yang CJ (2012) L-DNA molecular beacon: a safe, stable, and accurate intracellular nano-thermometer for temperature sensing in living cells. J Am Chem Soc 134:18908CrossRef PubMed
  Keefe AD, Pai S, Ellington A (2010) Aptamers as therapeutics. Nat Rev Drug Discov 9:537CrossRef PubMed
  Kelly KL, Coronado E, Zhao LL, Schatz GC (2003) The optical properties of metal nanoparticles: the influence of size, shape, and dielectric environment. J Phys Chem B 107:668CrossRef
  Kemin W, Zhiwen T, Yang CJ, Youngmi K, Xiaohong F, Wei L, Yanrong W, Medley CD, Zehui C, Jun L, Colon P, Hui L, Weihong T (2009) Molecular engineering of DNA: molecular beacons. Angew Chem Int Ed 48:856CrossRef
  Kim D, Jeong YY, Jon S (2010) A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer. ACS nano 4:3689CrossRef PubMed
  Li JWJ, Fang XH, Tan WH (2002) Molecular aptamer beacons for real-time protein recognition. Biochem Biophys Res Commun 292:31CrossRef PubMed
  Li J, Zhong X, Cheng F, Zhang J-R, Jiang L-P, Zhu J-J (2012) One-pot synthesis of aptamer-functionalized silver nanoclusters for cell-type-specific imaging. Anal Chem 84:4140CrossRef PubMed
  Li C, Chen T, Ocsoy I, Zhu G, Yasun E, You M, Wu C, Zheng J, Song E, Huang CZ, Tan W (2014) Gold-coated Fe 3 O 4 nanoroses with five unique functions for cancer cell targeting, imaging, and therapy. Adv Funct Mater 24:1772PubMedCentral CrossRef PubMed
  Liu J, Lu Y (2006a) Preparation of aptamer-linked gold nanoparticle purple aggregates for colorimetric sensing of analytes. Nat Protoc 1:246CrossRef PubMed
  Liu JW, Lu Y (2006b) Fast colorimetric sensing of adenosine and cocaine based on a general sensor design involving aptamers and nanoparticles. Angew Chem Int Ed 45:90CrossRef
  Mankoff DA (2007) A definition of molecular imaging. J Nucl Med 48:18NPubMed
  Mao G-J, Wei T-T, Wang X-X, Huan S-y L-Q, Zhang J, Zhang X-B, Tan W, Shen G-L, Yu R-Q (2013) High-sensitivity naphthalene-based two-photon fluorescent probe suitable for direct bioimaging of H2S in living cells. Anal Chem 85:7875CrossRef PubMed
  Massoud TF, Gambhir SS (2003) Molecular imaging in living subjects: seeing fundamental biological processes in a new light. Genes Dev 17:545CrossRef PubMed
  Medintz IL, Uyeda HT, Goldman ER, Mattoussi H (2005) Quantum dot bioconjugates for imaging, labelling and sensing. Nat Mater 4:435CrossRef PubMed
  Medley CD, Smith JE, Tang Z, Wu Y, Bamrungsap S, Tan W (2008) Gold nanoparticle-based colorimetric assay for the direct detection of cancerous cells. Anal Chem 80:1067CrossRef PubMed
  Medley CD, Bamrungsap S, Tan W, Smith JE (2011) Aptamer-conjugated nanoparticles for cancer cell detection. Anal Chem 83:727PubMedCentral CrossRef PubMed
  Michalet X, Pinaud FF, Bentolila LA, Tsay JM, Doose S, Li JJ, Sundaresan G, Wu AM, Gambhir SS, Weiss S (2005) Quantum dots for live cells, in vivo imaging, and diagnostics. Science 307:538PubMedCentral CrossRef PubMed
  Mortele KJ, McTavish J, Ros PR (2002) Current techniques of computed tomography. Helical CT, multidetector CT, and 3D reconstruction. Clin Liver Dis 6:29CrossRef PubMed
  Nakatsuka MA, Mattrey RF, Esener SC, Cha JN, Goodwin AP (2012) Aptamer-crosslinked microbubbles: smart contrast agents for thrombin-activated ultrasound imaging. Adv Mater 24:6010PubMedCentral CrossRef PubMed
  Ng EWM, Shima DT, Calias P, Cunningham ET, Guyer DR, Adamis AP (2006) Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular disease. Nat Rev Drug Discov 5:123CrossRef PubMed
  Pathak AP, Gimi B, Glunde K, Ackerstaff E, Artemov D, Bhujwalla ZM (2004) Molecular and functional imaging of cancer: advances in MRI and MRS. Imag Biol Res Part B 386:3
  Pavlov V, Xiao Y, Shlyahovsky B, Willner I (2004) Aptamer-functionalized Au nanoparticles for the amplified optical detection of thrombin. J Am Chem Soc 126:11768CrossRef PubMed
  Popovtzer R, Agrawal A, Kotov NA, Popovtzer A, Balter J, Carey TE, Kopelman R (2008) Targeted gold nanoparticles enable molecular CT imaging of cancer. Nano Lett 8:4593PubMedCentral CrossRef PubMed
  Qiu L, Wu C, You M, Han D, Chen T, Zhu G, Jiang J, Yu R, Tan W (2013) A targeted, self-delivered, and photocontrolled molecular beacon for mRNA detection in living cells. J Am Chem Soc 135:12952PubMedCentral CrossRef PubMed
  Reuveni T, Motiei M, Romman Z, Popovtzer A, Popovtzer R (2011) Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study. Int J Nanomed 6:2859
  Rosi NL, Mirkin CA (2005) Nanostructures in biodiagnostics. Chem Rev 105:1547CrossRef PubMed
  Shangguan D, Li Y, Tang Z, Cao ZC, Chen HW, Mallikaratchy P, Sefah K, Yang CJ, Tan W (2006) Aptamers evolved from live cells as effective molecular probes for cancer study. Proc Natl Acad Sci USA 103:11838PubMedCentral CrossRef PubMed
  Shangguan D, Cao Z, Meng L, Mallikaratchy P, Sefah K, Wang H, Li Y, Tan W (2008) Cell-specific aptamer probes for membrane protein elucidation in cancer cells. J Proteome Res 7:2133PubMedCentral CrossRef PubMed
  Shi H, He X, Cui W, Wang K, Deng K, Li D, Xu F (2014) Locked nucleic acid/DNA chimeric aptamer probe for tumor diagnosis with improved serum stability and extended imaging window in vivo. Anal Chim Acta 812:138CrossRef PubMed
  Sokolov K, Aaron J, Hsu B, Nida D, Gillenwater A, Follen M, MacAulay C, Adler-Storthz K, Korgel B, Descour M, Pasqualini R, Arap W, Lam W, Richards-Kortum R (2003) Optical systems for in vivo molecular imaging of cancer. Technol Cancer Res Treat 2:491CrossRef PubMed
  Sun YG, Xia YN (2002) Shape-controlled synthesis of gold and silver nanoparticles. Science 298:2176CrossRef PubMed
  Tan WH, Wang KM, Drake TJ (2004) Molecular beacons. Curr Opin Chem Biol 8:547CrossRef PubMed
  Tan X, Chen T, Xiong X, Mao Y, Zhu G, Yasun E, Li C, Zhu Z, Tan W (2012) Semiquantification of ATP in live cells using nonspecific desorption of DNA from graphene oxide as the internal reference. Anal Chem 84:8622PubMedCentral CrossRef PubMed
  Tao C, Cuichen Sam W, Jimenez E, Zhi Z, Dajac JG, Mingxu Y, Da H, Xiaobing Z, Weihong T (2013) DNA Micelle Flares for intracellular mRNA imaging and gene therapy. Angew Chem Int Ed 52:2012CrossRef
  Tuerk C, Gold L (1990) Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science (New York, N.Y.) 249:505CrossRef
  Wang F, Liu X (2009) Recent advances in the chemistry of lanthanide-doped upconversion nanocrystals. Chem Soc Rev 38:976CrossRef PubMed
  Wang LY, Yan RX, Hao ZY, Wang L, Zeng JH, Bao J, Wang X, Peng Q, Li YD (2005) Fluorescence resonant energy transfer biosensor based on upconversion-luminescent nanoparticles. Angew Chem Int Ed 44:6054CrossRef
  Wang AZ, Bagalkot V, Vasilliou CC, Gu F, Alexis F, Zhang L, Shaikh M, Yuet K, Cima MJ, Langer R, Kantoff PW, Bander NH, Jon S, Farokhzad OC (2008a) Superparamagnetic iron oxide nanoparticle-aptamer bioconjugates for combined prostate cancer imaging and therapy. ChemMedChem 3:1311PubMedCentral CrossRef PubMed
  Wang Y, Li D, Ren W, Liu Z, Dong S, Wang E (2008b) Ultrasensitive colorimetric detection of protein by aptamer-Au nanoparticles conjugates based on a dot-blot assay. Chem Commun 2008:2520CrossRef
  Wang Y, Li Z, Hu D, Lin C-T, Li J, Lin Y (2010) Aptamer/graphene oxide nanocomplex for in situ molecular probing in living cells. J Am Chem Soc 132:9274CrossRef PubMed
  Wang J, Wei T, Li X, Zhang B, Wang J, Huang C, Yuan Q (2014) Near-infrared-light-mediated imaging of latent fingerprints based on molecular recognition. Angew Chem Int Ed 53:1616CrossRef
  Winnard PT Jr, Pathak AP, Dhara S, Cho SY, Raman V, Pomper MG (2008) Molecular imaging of metastatic potential. J Nucl Med 49:96SCrossRef PubMed
  Winter PM, Caruthers SD, Wickline SA, Lanza GM (2006) Molecular imaging by MRI. Curr Cardiol Rep 8:65CrossRef PubMed
  Wu C, Chen T, Han D, You M, Peng L, Cansiz S, Zhu G, Li C, Xiong X, Jimenez E, Yang CJ, Tan W (2013) Engineering of switchable aptamer micelle flares for molecular imaging in living cells. ACS Nano 7:5724PubMedCentral CrossRef PubMed
  Yang CJ, Jockusch S, Vicens M, Turro NJ, Tan WH (2005) Light-switching excimer probes for rapid protein monitoring in complex biological fluids. Proc Natl Acad Sci USA 102:17278PubMedCentral CrossRef PubMed
  Yuan Q, Wu Y, Wang J, Lu D, Zhao Z, Liu T, Zhang X, Tan W (2013) Targeted bioimaging and photodynamic therapy nanoplatform using an aptamer-guided G-quadruplex DNA carrier and near-infrared light. Angew Chem Int Ed 52:13965CrossRef
  Zhang ZD, Nair SA, McMurry TJ (2005) Gadolinium meets medicinal chemistry: MRI contrast agent development. Curr Med Chem 12:751CrossRef PubMed
  Zhao Z, Fan H, Zhou G, Bai H, Liang H, Wang R, Zhang X, Tan W (2014) Activatable fluorescence/MRI bimodal platform for tumor cell imaging via MnO2 nanosheet-aptamer nanoprobe. J Am Chem Soc 136:11220CrossRef PubMed
  Zhong H, Zhang Q, Zhang S (2011) High-intensity fluorescence imaging and sensitive electrochemical detection of cancer cells by using an extracellular supramolecular reticular DNA-quantum dot sheath. Chem-Eur J 17:8388CrossRef PubMed
  Zhu G, Hu R, Zhao Z, Chen Z, Zhang X, Tan W (2013a) Noncanonical self-assembly of multifunctional DNA nanoflowers for biomedical applications. J Am Chem Soc 135:16438CrossRef PubMed
  Zhu G, Zheng J, Song E, Donovan M, Zhang K, Liu C, Tan W (2013b) Self-assembled, aptamer-tethered DNA nanotrains for targeted transport of molecular drugs in cancer theranostics. Proc Natl Acad Sci USA 110:7998PubMedCentral CrossRef PubMed
  
• 作者单位：Cheng Jin (1)
  Jing Zheng (1)
  Chunmei Li (2)
  Liping Qiu (1) (3)
  Xiaobing Zhang (1)
  Weihong Tan (1) (3)
  
  1. Molecular Science and Biomedicine Laboratory, State Key Laboratory of Chemo/Bio-Sensing and Chemometrics, College of Chemistry and Chemical Engineering and College of Biology, and Collaborative Research Center of Molecular Engineering for Theranostics, Hunan University, Changsha, 410082, China
  2. Key Laboratory of Luminescent and Real-Time Analytical Chemistry, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, China
  3. Department of Chemistry and Department of Physiology and Functional Genomics, Center for Research at Bio/Nano Interface, Health Cancer Center, UF Genetics Institute and McKnight Brain Institute, University of Florida, Gainesville, FL, 32611-7200, USA
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Cell Biology
  Microbiology
  Plant Sciences
  
• 出版者：Springer New York
• ISSN：1432-1432

文摘

Conventional diagnostics for cancer rely primarily on anatomical techniques. However, these techniques cannot monitor the changes at the molecular level in normal cells, which possibly signal the onset of cancer at its very earliest stages. For accurate prediction of the carcinogenesis at the molecular level, targeting ligands have been used in combination with imaging probes to monitor this biological process. Among these targeting ligands, aptamers have high binding affinity to various targets ranging from small molecules to whole organisms, and, hence, exceptional recognition ability. Many recent studies have been reported on aptamer-based molecular imaging, clearly indicating its clinical and diagnostic utility. In this review, we will discuss some key results of these studies. Keywords Aptamer SELEX Molecular imaging Cancer Targeting ligands