Malignant lipogenesis defined by ¹¹C-acetate PET/CT predicts prostate cancer-specific survival in patients with biochemical relapse after prostatectomy

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• 作者：Naresh Regula ; Michael Häggman…
• 关键词：11C ; Acetate ; Positron emission tomography ; Prostate carcinoma ; Survival analysis ; Malignant lipogenesis ; Fatty acid synthase
• 刊名：European Journal of Nuclear Medicine and Molecular Imaging
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：43
• 期：12
• 页码：2131-2138
• 全文大小：470 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Nuclear Medicine
  Imaging and Radiology
  Orthopedics
  Cardiology
  Oncology
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1619-7089
• 卷排序：43

文摘

PurposeMalignant de novo lipogenesis is strongly linked to the aggressiveness of prostate cancer (PCa) under experimental conditions. 11C-Acetate PET/CT is a potential noninvasive biomarker of malignant lipogenesis in PCa, but its prognostic value is not known. The objective of this study was to analyse 11C-acetate PET/CT image metrics in relation to survival.