Compatibility study between lipoic acid with polymers used in controlled drug release systems
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- 作者：Paulo César D. Silva ; Alyne S. Portela…
- 关键词：Lipoic acid ; Polymers ; Compatibility ; DSC ; Solid ; state characterization
- 刊名：Journal of Thermal Analysis and Calorimetry
- 出版年：2016
- 出版时间：February 2016
- 年：2016
- 卷：123
- 期：2
- 页码：965-971
- 全文大小：826 KB
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Alyne S. Portela (2)
Rosemary Sousa C. Lima (1)
Cleildo P. Santana (3)
Ana Cláudia D. Medeiros (3)
Mônica Oliveira da Silva Simões (3)
1. Laboratory of Biomaterials Development and Evaluation of the Northeast – CERTBIO, Department of Pharmacy, Center of Biological and Health Sciences, State University of Paraíba, Campina Grande, PB, CEP 58429-500, Brazil
3. Laboratory of Development and Assays in Medicines, Center of Biological and Health Sciences, State University of Paraíba, Campina Grande, PB, CEP 58429-500, Brazil
2. Department of Medicine, College of Medical Sciences of Campina Grande, Campina Grande, PB, CEP 58411-020, Brazil - 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry
Sciences
Polymer Sciences
Physical Chemistry
Inorganic Chemistry
Measurement Science and Instrumentation - 出版者：Akad茅miai Kiad贸, co-published with Springer Science+Business Media B.V., Formerly Kluwer Academic
- ISSN：1572-8943
文摘
Lipoic acid is derived from octanoic acid and is considered a universal antioxidant for combating free radicals and regeneration of endogenous antioxidant, as well as acting like an essential cofactor in multienzyme mitochondrial complex. In the pharmaceutical field, the polymers are among used excipients in pharmaceutical technology, especially in therapies controlled release of drugs. The aim of this study was to evaluate the drug–excipient compatibility between the AL and excipients used in controlled release drug delivery systems. To investigate the possible interactions between substances, was initially performed one screening with differential scanning calorimetry (DSC) to detect possible interactions, and analyses were performed by infrared spectroscopy (FTIR) to confirm the possible interactions. Based on the results of DSC and FTIR was found to be incompatible only with PVP-K30. Based on these results, we can conclude that the analytical tools used in this study are effective for defining incompatibilities between drugs and pharmaceutical excipients in order to ensure a new formulation with well-defined parameters of quality control and stability. Keywords Lipoic acid Polymers Compatibility DSC Solid-state characterization