Inhibitory effect of polyethylene oxide and polypropylene oxide triblock copolymers on aggregation and fusion of atherogenic low density lipoproteins

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• 作者：I. G. Panova ; V. V. Spiridonov ; I. B. Kaplan ; S. S. Trubinov…
• 关键词：low density lipoproteins ; pluronics ; triblock copolymers of poly(ethylene oxide) and poly(propylene oxide) ; atherosclerosis ; anti ; atherogenicity ; inhibition of aggregation and fusion
• 刊名：Biochemistry (Moscow)
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：80
• 期：8
• 页码：1057-1064
• 全文大小：1,082 KB
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• 作者单位：I. G. Panova (1)
  V. V. Spiridonov (1)
  I. B. Kaplan (2)
  S. S. Trubinov (3)
  N. V. Elizova (3)
  A. A. Melnichenko (3)
  A. N. Orekhov (3)
  A. A. Yaroslavov (1)
  
  1. Lomonosov Moscow State University, Faculty of Chemistry, 119991, Moscow, Russia
  2. Lomonosov Moscow State University, Faculty of Biology, 119991, Moscow, Russia
  3. Institute of General Pathology and Pathophysiology, Russian Academy of Medical Sciences, 125315, Moscow, Russia
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Life Sciences
  Biochemistry
  Bioorganic Chemistry
  Microbiology
  Biomedicine
  Russian Library of Science
  
• 出版者：MAIK Nauka/Interperiodica distributed exclusively by Springer Science+Business Media LLC.
• ISSN：1608-3040

文摘

Triblock copolymers of poly(ethylene oxide) and poly(propylene oxide) (so-called pluronics) were shown to influence the aggregation and fusion of atherogenic low density lipoproteins (atLDL) and be able to inhibit these processes. The character of the influence and the degree of the stabilizing effect depended on the structure, relative hydrophobicity, and concentration of the copolymer. Pluronics L61, P85, and L64 characterized by the hydrophilic–lipophilic balance (HLB) value from 3 to 16 had the greatest ability to suppress the aggregation of atLDL. Pluronic L81 with the higher hydrophobicity (HLB = 2) partially inhibited atLDL aggregation at low concentrations but stimulated it at high concentrations. The influence of pluronics did not have a direct connection with their ability for micelle formation, but it was realized through individual macromolecules. We suppose that effects of pluronics could be due to their interaction with the lipid component of LDL and to a possible influence of these copolymers on the structure and hydrophilic–lipophilic characteristics of lipoproteins.