Molecular network of important genes for systemic sclerosis-related progressive lung fibrosis
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- 作者：Yan Jiao ; Hong Chen ; Tianshu Gu ; Lishi Wang ; Arnold Postlethwaite…
- 关键词：Gene network ; Human ; Mouse ; Lung fibrosis ; Systemic sclerosis
- 刊名：BMC Research Notes
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：8
- 期：1
- 全文大小：1,490 KB
- 刊物主题：Biomedicine general; Medicine/Public Health, general; Life Sciences, general;
- 出版者：BioMed Central
- ISSN：1756-0500
文摘
Background Considerable progress has been made in illuminating the pathological events for systemic sclerosis (SSc)-related progressive lung fibrosis. The molecular events that lead to SSc-related progressive lung fibrosis need to be defined. Some important genes have been identified from a recent study in humans. We aim to construct and compare the similarities and differences of molecular pathways between SSc-related progressive lung fibrosis and normal lungs of humans and mice.