Astragalus polysaccharide enhances immunity and inhibits H9N2 avian influenza virus in vitro and in vivo
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- 作者：Sanpha Kallon (1)
Xiaorong Li (1)
Jun Ji (1)
Cuiying Chen (1)
Qianyun Xi (1)
Shuang Chang (2)
Chunyi Xue (3)
Jingyun Ma (1)
Qingmei Xie (1)
Youngliang Zhang (1) - 关键词：Astragalus polysaccharide ; H9N2 avian influenza virus ; Immune effect
- 刊名：Journal of Animal Science and Biotechnology
- 出版年：2013
- 出版时间：December 2013
- 年：2013
- 卷：4
- 期：1
- 全文大小：384KB
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Xiaorong Li (1)
Jun Ji (1)
Cuiying Chen (1)
Qianyun Xi (1)
Shuang Chang (2)
Chunyi Xue (3)
Jingyun Ma (1)
Qingmei Xie (1)
Youngliang Zhang (1)
1. College of Animal Science, South China Agricultural University, Guangzhou, 510642, China
2. US Department of Agriculture, Avian Disease and Oncology Laboratory, Agricultural Research Service, 3606 East Mount Hope Road, East Lansing, MI, 48823, USA
3. State Key Laboratory of Biocontrol, College of Life Sciences, Sun Yat-Sen University, Guangzhou, 510006, China
文摘
This study investigated the humoral immunization of Astragalus polysaccharide (APS) against H9N2 avian influenza virus (H9N2 AIV) infection in chickens. The effects of APS treatment on H9N2 infection was evaluated by an MTT [3(4, 5-dimethylthiazol-2-yl)-2, 3-diphenyl tetrazolium bromide] assay and analysis of MHC and cytokine mRNA expression. The effect on lymphocyte and serum antibody titers in vivo was also investigated. IL-4, IL-6, IL-10, LITAF, IL-12 and antibody titers to H9N2 AIV were enhanced in the first week after APS treatment. The results indicated that APS treatment reduces H9N2 AIV replication and promotes early humoral immune responses in young chickens.