Liver transplantation nearly normalizes brain spontaneous activity and cognitive function at 1?month: a resting-state functional MRI study

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• 作者：Yue Cheng ; Lixiang Huang ; Xiaodong Zhang ; Jianhui Zhong ; Qian Ji…
• 关键词：Liver transplantation ; Resting ; state functional magnetic resonance imaging ; Regional homogeneity ; Hepatic encephalopathy ; Cirrhosis
• 刊名：Metabolic Brain Disease
• 出版年：2015
• 出版时间：August 2015
• 年：2015
• 卷：30
• 期：4
• 页码：979-988
• 全文大小：2,810 KB
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• 作者单位：Yue Cheng (1)
  Lixiang Huang (1)
  Xiaodong Zhang (1) (2)
  Jianhui Zhong (3)
  Qian Ji (1)
  Shuangshuang Xie (1)
  Lihua Chen (1)
  Panli Zuo (4)
  Long Jiang Zhang (2)
  Wen Shen (1)
  
  1. Department of Radiology, Tianjin First Central Hospital, No.24 Fu Kang Road, Nan Kai District, Tianjin, 300192, China
  2. Department of Medical Imaging, Jinling Hospital, Medical School of Nanjing University, 305 Zhongshan East Road, Xuanwu District, Nanjing, Jiangsu Province, 210002, China
  3. Department of Biomedical Engineering, Zhejiang University, Hangzhou, 310027, China
  4. Siemens Healthcare, MR Collaborations NE Asia, Beijing, 100102, China
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Neurosciences
  Neurology
  Biochemistry
  Oncology
  
• 出版者：Springer Netherlands
• ISSN：1573-7365

文摘

To investigate the short-term brain activity changes in cirrhotic patients with Liver transplantation (LT) using resting-state functional MRI (fMRI) with regional homogeneity (ReHo) method. Twenty-six cirrhotic patients as transplant candidates and 26 healthy controls were included in this study. The assessment was repeated for a sub-group of 12 patients 1?month after LT. ReHo values were calculated to evaluate spontaneous brain activity and whole brain voxel-wise analysis was carried to detect differences between groups. Correlation analyses were performed to explore the relationship between the change of ReHo with the change of clinical indexes pre- and post-LT. Compared to pre-LT, ReHo values increased in the bilateral inferior frontal gyrus (IFG), right inferior parietal lobule (IPL), right supplementary motor area (SMA), right STG and left middle frontal gyrus (MFG) in patients post-LT. Compared to controls, ReHo values of post-LT patients decreased in the right precuneus, right SMA and increased in bilateral temporal pole, left caudate, left MFG, and right STG. The changes of ReHo in the right SMA, STG and IFG were correlated with change of digit symbol test (DST) scores (P?<?0.05 uncorrected). This study found that, at 1?month after LT, spontaneous brain activity of most brain regions with decreased ReHo in pre-LT was substantially improved and nearly normalized, while spontaneous brain activity of some brain regions with increased ReHo in pre-LT continuously increased. ReHo may provide information on the neural mechanisms of LT-effects on brain function.