Measurement and Correlation of Solubility of Nitrendipine in Supercritical Carbon Dioxide With and Without Ethanol Cosolvent

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• 作者：Shiping Zhan ; Liyun Cui ; Qicheng Zhao ; Li Chen…
• 关键词：Nitrendipine solubility ; Supercritical carbon dioxide ; Cosolvent ; Semi ; empirical model
• 刊名：Journal of Solution Chemistry
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：44
• 期：1
• 页码：1-15
• 全文大小：308 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Physical Chemistry
  Industrial Chemistry and Chemical Engineering
  Geochemistry
  Oceanography
  Inorganic Chemistry
  Condensed Matter
  
• 出版者：Springer Netherlands
• ISSN：1572-8927

文摘

The solubilities of nitrendipine in supercritical carbon dioxide (ScCO2) and in the presence of 1, 3, 5, and 7?mol.% ethanol, were measured at 308, 318, and 328?K over a pressure range of 8-0?MPa. The experimental results reveal that the solubility increased with increasing pressure; the effect of temperature was more complex with or without cosolvent. The solubilities obtained in pure ScCO2 are relatively low, and they were successfully correlated by two semi-empirical models (Chrastil, Sung and Shim (SS) models). The solubility is increased significantly with ethanol as cosolvent, and these data were also correlated well using the modified Méndez-Santiago and Teja (M-ST) models.