Spatial and temporal expression of c-Kit in the development of the murine submandibular gland
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- 作者：Xuejiu Wang (1)
Senrong Qi (1)
Jinsong Wang (1) (3)
Dengsheng Xia (1)
Lizheng Qin (1)
Zongmei Zheng (1)
Liping Wang (1)
Chunmei Zhang (1)
Luyuan Jin (1)
Gang Ding (1)
Songlin Wang (1) (3)
Zhipeng Fan (2) - 关键词：c ; Kit ; Submandibular gland ; Development ; Mouse
- 刊名：Journal of Molecular Histology
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：45
- 期：4
- 页码：381-389
- 全文大小：18,295 KB
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Senrong Qi (1)
Jinsong Wang (1) (3)
Dengsheng Xia (1)
Lizheng Qin (1)
Zongmei Zheng (1)
Liping Wang (1)
Chunmei Zhang (1)
Luyuan Jin (1)
Gang Ding (1)
Songlin Wang (1) (3)
Zhipeng Fan (2)
1. Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, 100050, China
3. Department of Biochemistry and Molecular Biology, Capital Medical University School of Basic Medical Sciences, Beijing, 100069, China
2. Laboratory of Molecular Signaling and Stem Cells Therapy, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Capital Medical University School of Stomatology, Beijing, 100050, China - ISSN：1567-2387
文摘
The c-Kit pathway is important in the development of many mammalian cells and organs and is indispensable for the development of hematopoiesis, melanocytes, and primordial germ cells. Loss-of-function mutations in c-Kit lead to perinatal death in mouse embryos. Previously, c-Kit has been used as one of salivary epithelial stem or progenitor cell markers in mouse, its specific temporo-spatial expression pattern and function in developing murine submandibular gland (SMG) is still unclear. Here we used quantitative real-time PCR, in situ hybridization, and immunohistochemistry analysis to detect c-Kit expression during the development of the murine SMG. We found that c-Kit was expressed in the epithelia of developing SMGs from embryonic day 11.5 (E11.5; initial bud stage) to postnatal day 90 (P90; when the SMG is completely mature). c-Kit expression in the end bud epithelium increased during prenatal development and then gradually decreased after birth until its expression was undetectable in mature acini at P30. Moreover, c-Kit was expressed in the SMG primordial cord at the initial bud, pseudoglandular, canacular, and terminal end bud stages. c-Kit was also expressed in the presumptive ductal cells adjacent to the developing acini. By the late terminal end bud stage on P14, c-Kit expression could not be detected in ductal cells. However, c-Kit expression was detected in ductal cells at P30, and its expression had increased dramatically at P90. Taken together, these findings describe the spatial and temporal expression pattern of c-Kit in the developing murine SMG and suggest that c-Kit may play roles in epithelial histo-morphogenesis and in ductal progenitor cell homeostasis in the SMG.