PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression

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• 作者：Vandna Shah ; Salpie Nowinski ; Dina Levi ; Irek Shinomiya…
• 关键词：Lobular carcinoma in situ ; Somatic copy number aberrations ; CCND1 ; PIK3CA ; Heterogeneity
• 刊名：Breast Cancer Research
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：2402KB
• 刊物主题：Cancer Research; Oncology; Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1465-542X
• 卷排序：19

文摘

BackgroundLobular carcinoma in situ (LCIS) is a non-invasive breast lesion that is typically found incidentally on biopsy and is often associated with invasive lobular carcinoma (ILC). LCIS is considered by some to be a risk factor for future breast cancer rather than a true precursor lesion. The aim of this study was to identify genetic changes that could be used as biomarkers of progression of LCIS to invasive disease using cases of pure LCIS and comparing their genetic profiles to LCIS which presented contemporaneously with associated ILC, on the hypothesis that the latter represents LCIS that has already progressed.