CARDIO-PRED: an in silico tool for predicting cardiovascular-disorder associated proteins

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• 作者：Prerna Jain ; Nitin Thukral ; Lokesh Kumar Gahlot…
• 关键词：Interface properties ; Cardiovascular ; disorder ; Machine learning ; 3 ; Dimensional structure ; Network analysis
• 刊名：Systems and Synthetic Biology
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：9
• 期：1-2
• 页码：55-66
• 全文大小：2,290 KB
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• 作者单位：Prerna Jain (1)
  Nitin Thukral (1)
  Lokesh Kumar Gahlot (1)
  Yasha Hasija (1)
  
  1. Department of Biotechnology, Delhi Technological University, Shahbad Daulatpur, Main Bawana Road, Delhi, 110042, India
  
• 刊物主题：Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：1872-5333

文摘

Interactions between proteins largely govern cellular processes and this has led to numerous efforts culminating in enormous information related to the proteins, their interactions and the function which is determined by their interactions. The main concern of the present study is to present interface analysis of cardiovascular-disorder (CVD) related proteins to shed lights on details of interactions and to emphasize the importance of using structures in network studies. This study combines the network-centred approach with three dimensional studies to comprehend the fundamentals of biology. Interface properties were used as descriptors to classify the CVD associated proteins and non-CVD associated proteins. Machine learning algorithm was used to generate a classifier based on the training set which was then used to predict potential CVD related proteins from a set of polymorphic proteins which are not known to be involved in any disease. Among several classifying algorithms applied to generate models, best performance was achieved using Random Forest with an accuracy of 69.5?%. The tool named CARDIO-PRED, based on the prediction model is present at http://?www.?genomeinformatic?s.?dce.?edu/?CARDIO-PRED/-/span>. The predicted CVD related proteins may not be the causing factor of particular disease but can be involved in pathways and reactions yet unknown to us thus permitting a more rational analysis of disease mechanism. Study of their interactions with other proteins can significantly improve our understanding of the molecular mechanism of diseases.