Higher frequencies of HLA DQB1*05:01 and anti-glycosphingolipid antibodies in a cluster of severe Guillain–Barré syndrome
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- 作者：L. Schirmer ; V. Worthington ; U. Solloch ; V. Loleit ; V. Grummel…
- 关键词：Guillain–Barré syndrome (GBS) ; Campylobacter jejuni ; HLA class II alleles ; Glycosphingolipids ; Autoantibodies
- 刊名：Journal of Neurology
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：263
- 期：10
- 页码：2105-2113
- 全文大小：784 KB
- 刊物类别：Medicine
- 刊物主题：Medicine & Public Health
Neurology
Neurosciences
Neuroradiology - 出版者：Springer Berlin / Heidelberg
- ISSN：1432-1459
- 卷排序：263
文摘
Few regional and seasonal Guillain–Barré syndrome (GBS) clusters have been reported so far. It is unknown whether patients suffering from sporadic GBS differ from GBS clusters with respect to clinical and paraclinical parameters, HLA association and antibody response to glycosphingolipids and Campylobacter jejuni (Cj). We examined 40 consecutive patients with GBS from the greater Munich area in Germany with 14 of those admitted within a period of 3 months in fall 2010 defining a cluster of GBS. Sequencing-based HLA typing of the HLA genes DRB1, DQB1, and DPB1 was performed, and ELISA for anti-glycosphingolipid antibodies was carried out. Clinical and paraclinical findings (Cj seroreactivity, cerebrospinal fluid parameters, and electrophysiology) were obtained and analyzed. GBS cluster patients were characterized by a more severe clinical phenotype with more patients requiring mechanical ventilation and higher frequencies of autoantibodies against sulfatide, GalC and certain ganglioside epitopes (54 %) as compared to sporadic GBS cases (13 %, p = 0.017). Cj seropositivity tended to be higher within GBS cluster patients (69 %) as compared to sporadic cases (46 %, p = 0.155). We noted higher frequencies of HLA class II allele DQB1*05:01 in the cluster cohort (23 %) as compared to sporadic GBS patients (3 %, p = 0.019). Cluster of severe GBS was defined by higher frequencies of autoantibodies against glycosphingolipids. HLA class II allele DQB1*05:01 might contribute to clinical worsening in the cluster patients.