Second trimester amniotic fluid retinol in patients developing preeclampsia

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• 作者：A. Fruscalzo ; A. P. Londero ; J. Biasizzo…
• 关键词：Preeclampsia ; Amniotic fluid ; Vitamin A ; Retinol ; Uric acid ; Vitamin E ; Malondialdehyde
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2015
• 出版时间：April 2015
• 年：2015
• 卷：291
• 期：4
• 页码：831-836
• 全文大小：182 KB
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  19. Vascot
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711

文摘

Background Retinol (ROH) is an essential micronutrient required for normal fetal development and an essential molecule for antioxidant processes. Objective To investigate the putative role of ROH as a marker of preeclampsia in early second trimester amniotic fluid (AF). Materials and methods Case–control study comparing the concentration of ROH and other antioxidants such as uric acid, vitamin E and malondialdehyde (MDA) in second trimester AF in patients that later developed preeclampsia with normal pregnancies. Results The concentration of ROH in amniotic fluids of women that later developed preeclampsia was significantly higher than those of uncomplicated pregnancies (66.72?μg/l (49.00-0.56) vs. 44.4?μg/l (31.9-1.17), p?p? Conclusions Second trimester AF ROH concentration was significantly higher in pregnancies that developed preeclampsia compared to normal pregnancies.