Alteration of the RANKL/RANK/OPG System in Periprosthetic Osteolysis with Septic Loosening

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• 作者：Long Wang ; Zixun Dai ; Jie Xie ; Hao Liao ; Cheng Lv ; Yihe Hu
• 关键词：RANKL/RANK/OPG system ; periprosthetic osteolysis ; septic loosening ; aseptic loosening ; interface membrane
• 刊名：Inflammation
• 出版年：2016
• 出版时间：February 2016
• 年：2016
• 卷：39
• 期：1
• 页码：218-227
• 全文大小：5,581 KB
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• 作者单位：Long Wang (1)
  Zixun Dai (1)
  Jie Xie (1)
  Hao Liao (1)
  Cheng Lv (1)
  Yihe Hu (1)
  
  1. Department of Orthopaedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, People’s Republic of China
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

The pathogenesis of periprosthetic osteolysis with septic loosening remains incompletely understood. The purpose of this study was to investigate whether expression of the RANKL/RANK/OPG system is altered in septic interface membranes (SIMs). Seventeen cases with a SIM, 26 cases with an aseptic interface membrane (AIM), and 12 cases with a normal synovium (NS) were assessed. Scanning and transmission electron microscopy (SEM and TEM, respectively) were used to observe the microscopic morphology of three tissue conditions. Differences in RANKL, RANK, and OPG expression at the mRNA level were assessed by real-time quantitative PCR, and differences at the protein level were assessed by immunohistochemical staining and Western blotting. SEM showed wear debris widely distributed on the AIM surface, and TEM showed Bacillus activity in the SIM. RANKL expression and the RANKL/OPG ratio were significantly increased in SIMs. Imbalance in the RANKL/RANK/OPG system is related to periprosthetic osteolysis with septic loosening but is not the only possible pathogenic mechanism. KEY WORDS RANKL/RANK/OPG system periprosthetic osteolysis septic loosening aseptic loosening interface membrane