Pleurotus giganteus (Berk. Karun & Hyde), the giant oyster mushroom inhibits NO production in LPS/H₂O₂ stimulated RAW 264.7 cells via STAT 3 and COX-2 pathways

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• 作者：Asweni Baskaran ; Kek Heng Chua…
• 关键词：Mushroom ; Pleurotus giganteus ; anti ; inflammation ; NO production ; Lipopolysaccharide ; Macrophage ; STAT 3 ; COX ; 2
• 刊名：BMC Complementary and Alternative Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：17
• 期：1
• 全文大小：872KB
• 刊物主题：Complementary & Alternative Medicine; Internal Medicine; Chiropractic Medicine;
• 出版者：BioMed Central
• ISSN：1472-6882
• 卷排序：17

文摘

BackgroundPleurotus giganteus (Berk. Karunarathna and K.D. Hyde), has been used as a culinary mushroom and is known to have medicinal properties but its potential as an anti-inflammatory agent to mitigate inflammation triggered diseases is untapped. In this study, the molecular mechanism underlying the protective effect of ethanol extract of P. giganteus (EPG) against lipopolysaccharide (LPS) and combination of LPS and hydrogen peroxide (H₂O₂)-induced inflammation on RAW 264.7 macrophages was investigated.