Plaque components affect wall stress in stented human carotid artery: A numerical study

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• 作者：Zhen-Min Fan ; Xiao Liu ; Cheng-Fei Du ; An-Qiang Sun ; Nan Zhang…
• 关键词：Atherosclerosis ; Plaque composition ; Carotid artery stenting ; Restenosis ; Finite ; element analysis
• 刊名：Acta Mechanica Sinica
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：6
• 页码：1149-1154
• 全文大小：
• 刊物类别：Engineering
• 刊物主题：Theoretical and Applied Mechanics; Classical and Continuum Physics; Engineering Fluid Dynamics; Computational Intelligence;
• 出版者：The Chinese Society of Theoretical and Applied Mechanics; Institute of Mechanics, Chinese Academy of
• ISSN：1614-3116
• 卷排序：32

文摘

Carotid artery stenting presents challenges of in-stent restenosis and late thrombosis, which are caused primarily by alterations in the mechanical environment of the artery after stent implantation. The present study constructed patient-specific carotid arterial bifurcation models with lipid pools and calcified components based on magnetic resonance imaging. We numerically analyzed the effects of multicomponent plaques on the distributions of von Mises stresses (VMSs) in the patient-specific models after stenting. The results showed that when a stent was deployed, the large soft lipid pool in atherosclerotic plaques cushioned the host artery and reduced the stress within the arterial wall; however, this resulted in a sharp increase of VMS in the fibrous cap. When compared with the lipid pool, the presence of the calcified components led to slightly increased stresses on the luminal surface. However, when a calcification was located close to the luminal surface of the host artery and the stenosis, the local VMS was elevated. Overall, compared with calcified components, large lipid pools severely damaged the host artery after stenting. Furthermore, damage due to the calcified component may depend on location.