Heterogeneity of CD8+ tumor-infiltrating lymphocytes in non-small-cell lung cancer: impact on patient prognostic assessments and comparison of quantification by different sampling strategies
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- 作者：Joseph M. Obeid ; Nolan A. Wages ; Yinin Hu…
- 关键词：Heterogeneity ; NSCLC ; Tumor ; infiltrating lymphocytes ; CD8 T cells ; Patient survival ; Tumor sampling strategies
- 刊名：Cancer Immunology, Immunotherapy
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：66
- 期：1
- 页码：33-43
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Oncology; Immunology; Cancer Research;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0851
- 卷排序：66
文摘
IntroductionInfiltration of non-small-cell lung cancer (NSCLC) by CD8+ T lymphocytes predicts improved patient survival; however, heterogeneity of intratumoral localization complicates this assessment. Strategies for tumor sampling may not accurately represent the whole tumor. We hypothesized that sampling strategies may alter the identification of tumors with high CD8 density and affect the prognostic significance.