Two cases of primary adult T-cell leukemia/lymphoma of bone: case reports and a review of the literature

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• 作者：Takuro Kuriyama ; Noriaki Kawano ; Kiyoshi Yamashita…
• 关键词：Adult T ; cell leukemia/lymphoma ; Primary bone lymphoma ; Central nervous system invasion
• 刊名：International Journal of Hematology
• 出版年：2016
• 出版时间：September 2016
• 年：2016
• 卷：104
• 期：3
• 页码：392-395
• 全文大小：579 KB
• 刊物主题：Hematology; Oncology;
• 出版者：Springer Japan
• ISSN：1865-3774
• 卷排序：104

文摘

Primary bone lymphomas comprise <1 % of all malignant lymphomas, and there have been only a limited number of reports on primary adult T-cell leukemia/lymphoma (ATLL) of bone. Here, we report two cases of primary ATLL of bone. The first case was a 41-year-old woman with multiple bone tumors. She was diagnosed with ATLL of the skull through biopsy and treated with chemotherapy. Although the bone lesions showed transient improvement, the subsequent central nervous system (CNS) invasion of ATLL occurred and she died 7 months after diagnosis. The second case was a 65-year-old man with right coxodynia. He was diagnosed with ATLL through right femoral biopsy, and the lesion improved with chemotherapy. However, CNS invasion of ATLL developed during chemotherapy, and he died 10 months after diagnosis. Both the patients with primary ATLL of the bone reported here experienced CNS invasion. Thus, ATLL treatment should aim to prevent CNS invasion at an early stage.