Clinical significance of UGT1A1 polymorphism and expression of ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A in gastric cancer
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- 作者：Yongkuan Cao ; Guohu Zhang ; Peihong Wang ; Jun Zhou ; Wei Gan…
- 关键词：Gastric cancer ; Individualized treatment ; TYMS ; TUBB3 ; STMN1 ; UGT1A1 polymorphism
- 刊名：BMC Gastroenterology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：408KB
- 刊物主题：Gastroenterology; Internal Medicine; Hepatology;
- 出版者：BioMed Central
- ISSN：1471-230X
- 卷排序：17
文摘
BackgroundIndividualized therapeutic regimen is a recently intensively pursued approach for targeting diseases, in which the search for biomarkers was considered the first and most important. Thus, the goal of this study was to investigate whether the UGT1A1, ERCC1, BRCA1, TYMS, RRM1, TUBB3, STMN1 and TOP2A genes are underlying biomarkers for gastric cancer, which, to our knowledge, has not been performed.