Breast- and Salivary Gland-Derived Adenoid Cystic Carcinomas: Potential Post-Transcriptional Divergencies. A Pilot Study Based on miRNA Expression Profiling of Four Cases and Review of the Potential Relevance of the Findings

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• 作者：Orsolya Kiss ; Anna-Mária T?kés ; Sándor Spisák…
• 关键词：Adenoid cystic carcinoma ; microRNA ; Breast ; Salivary gland
• 刊名：Pathology & Oncology Research
• 出版年：2015
• 出版时间：January 2015
• 年：2015
• 卷：21
• 期：1
• 页码：29-44
• 全文大小：1,682 KB
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• 作者单位：Orsolya Kiss (1)
  Anna-Mária T?kés (2)
  Sándor Spisák (3)
  Anna Szilágyi (4)
  Norbert Lippai (5)
  Borbála Székely (1)
  A. Marcell Szász (1)
  Janina Kulka (1)
  
  1. 2nd Department of Pathology, Semmelweis University, Budapest, Hungary
  2. MTA - SE -Tumor Progression Research Group, Budapest, Hungary
  3. 2nd Department of Internal Medicine, Semmelweis University, Budapest, Hungary
  4. Szent Gy?rgy Hospital, Székesfehérvár, Hungary
  5. Hetényi Géza Hospital, Szolnok, Hungary
  
• 刊物主题：Cancer Research; Oncology; Pathology; Immunology; Biomedicine general;
• 出版者：Springer Netherlands
• ISSN：1532-2807

文摘

Adenoid cystic carcinoma (ACC) is a malignant tumor of the salivary glands but identical tumors can also arise from the breast. Despite their similar histomorphological appearance the salivary gland- and the breast-derived forms differ in their clinical features: while ACC of the salivary glands (sACC) have an agressive clinical course, the breast-derived form (bACC) shows a very favourable clinical outcome. To date no exact molecular alterations have yet been identified which would explain the diverse clinical features of the ACCs of different origin. In our pilot experiment we investigated the post-transcriptional features of ACC cases by performing microRNA-profiling on 2-2 bACC and sACC tissues and on 1-1 normal breast and salivary gland tissue. By comparing the microRNA-profiles of the investigated samples we identified microRNAs which were expressed differently in bACC and sACC cases according to their normal controls: 7 microRNAs were overexpressed in sACC cases and downexpressed in bACC tumors (let-7b, let-7c, miR-17, miR-20a, miR-24, miR-195, miR-768-3) while 9 microRNAs were downexpressed in sACC cases and overexpressed in bACC tissues (let-7e, miR-23b, miR-27b, miR-193b, miR-320a, miR-320c, miR-768-5p, miR-1280 and miR-1826) relative to their controls. We also identified 8 microRNAs which were only expressed in sACCs and one microRNA (miR-1234) which was only absent in sACC cases. By target predictor online databases potential targets of the these microRNAs were detected to identify genes that may play central role in the diverse cinical outcome of bACC and sACC cases.