Statistical inference for homologous gene pairs between two circular genomes: a new circular–circular regression model

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• 作者：Ashis SenGupta ; Sungsu Kim
• 刊名：Statistical Methods & Applications
• 出版年：2016
• 出版时间：August 2016
• 年：2016
• 卷：25
• 期：3
• 页码：421-432
• 全文大小：415 KB
• 刊物类别：Mathematics and Statistics
• 刊物主题：Statistics
  Statistics
  Statistics for Business, Economics, Mathematical Finance and Insurance
  Economic Theory
  
• 出版者：Physica Verlag, An Imprint of Springer-Verlag GmbH
• ISSN：1613-981X
• 卷排序：25

文摘

In this paper, we investigate the problem of determining the relationship, represented by similarity of the homologous gene configuration, between paired circular genomes using a regression analysis. We propose a new regression model for studying two circular genomes, where the Möbius transformation naturally arises and is taken as the link function, and propose the least circular distance estimation method, as an appropriate method for analyzing circular variables. The main utility of the new regression model is in identification of a new angular location of one of a homologous gene pair between two circular genomes, for various types of possible gene mutations, given that of the other gene. Furthermore, we demonstrate the utility of our new regression model for grouping of various genomes based on closeness of their relationship. Using angular locations of homologous genes from the five pairs of circular genomes (Horimoto et al. in Bioinformatics 14:789–802, 1998), the new model is compared with the existing models.KeywordsCircular regressionCircular genomeCircular distance