Swimming exercise in infancy has beneficial effect on the hearts in cardiomyopathic Syrian hamsters
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- 作者：Mariko Tatsuguchi (1)
Eriko Hiratsuka (2)
Shuichi Machida (3)
Toshio Nishikawa (4)
Shin-Ichiro Imamura (2)
Satoru Shimizu (5)
Masahiko Nishimura (7)
Issei Komuro (8)
Yoshiyuki Furutani (3)
Michiko Furutani (3)
Hiroaki Nagao (2)
Keiko Komatsu (2)
Hiroshi Kasanuki (1)
Rumiko Matsuoka (3) (6) - 刊名：Journal of Muscle Research and Cell Motility
- 出版年：2004
- 出版时间：February 2004
- 年：2004
- 卷：25
- 期：1
- 页码：69-76
- 全文大小：256KB
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Eriko Hiratsuka (2)
Shuichi Machida (3)
Toshio Nishikawa (4)
Shin-Ichiro Imamura (2)
Satoru Shimizu (5)
Masahiko Nishimura (7)
Issei Komuro (8)
Yoshiyuki Furutani (3)
Michiko Furutani (3)
Hiroaki Nagao (2)
Keiko Komatsu (2)
Hiroshi Kasanuki (1)
Rumiko Matsuoka (3) (6)
1. Department of Cardiology, The Heart Institute of Japan, Japan
2. Research Division, The Heart Institute of Japan, Japan
3. Department of Pediatric Cardiology, The Heart Institute of Japan, Japan
4. Department of Pathology, Institute of Advanced Biochemical Engineering and Science, Graduate School of Medicine, Tokyo Women's Medical University, Tokyo, Japan
5. Department of Hygiene and Public Health, Institute of Advanced Biochemical Engineering and Science, Graduate School of Medicine, Tokyo Women's Medical University, Tokyo, Japan
7. Institute for Laboratory Animal Research, Nagoya University School of Medicine, Nagoya, Japan
8. Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, Chiba, Japan
6. Division of Genomic Medicine, Institute of Advanced Biochemical Engineering and Science, Graduate School of Medicine, Tokyo Women's Medical University, Tokyo, Japan
文摘
The phenotypic expression of cardiomyopathy is greatly influenced by extrinsic factors other than intrinsic genetic defects, such as environmental stress. Exercise is assumed to be an important extrinsic factor, since sudden death is sometimes seen during exercise in young patients with hypertrophic cardiomyopathy (HCM). However, the long-term effects of mild exercise on phenotypic expression in cardiomyopathy remain unclear. To evaluate the effects of exercise performed during infancy or adolescence in cardiomyopathic patients, cardiomyopathic Syrian hamsters (BIO14.6) were subjected to swimming. BIO14.6 and age-matched congenic normal hamsters (CN) as controls were divided into three groups: sedentary (Sed), and trained during infancy (Inf) and during adolescence (Ado). Histological and biochemical analysis of 41-week-old hamsters revealed that (1) the relative level of β-myosin heavy chain mRNA was significantly lower in the Inf group than in the Sed and Ado groups of BIO14.6. The level in the Inf group of BIO14.6 was compatible with that in the age-matched Sed group of the CN strain; (2) in BIO14.6, degenerative mitochondrial change in the cardiomyocytes was not seen in the Inf group while it was common in the Sed and Ado groups; (3) calcineurin phosphatase activity in the swimming group in 10-week-old CN was significantly higher than that of the age-matched sedentary group, and was as much as that of the swimming and sedentary groups in 10- and 41-week-old BIO14.6.