Bone marrow-derived macrophages from aged rats are more responsive to inflammatory stimuli

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• 作者：James P Barrett ; Derek A Costello ; Joan O'Sullivan…
• 关键词：Age ; Bone marrow ; derived macrophages ; Macrophage phenotypes ; Lipopolysaccharide (LPS) ; Interferon ; γ (IFNγ) ; Inflammatory cytokines
• 刊名：Journal of Neuroinflammation
• 出版年：2015
• 出版时间：December 2015
• 年：2015
• 卷：12
• 期：1
• 全文大小：835 KB
• 刊物主题：Neurosciences; Neurology; Neurobiology; Immunology;
• 出版者：BioMed Central
• ISSN：1742-2094

文摘

Background Lipopolysaccharide (LPS) and interferon-γ (IFNγ) increase expression of tumour necrosis factor-α (TNFα) that characterizes the M1 activation state of macrophages. Whereas it is accepted that the immune system undergoes changes with age, there is inconsistency in the literature with respect to the impact of age on the response of macrophages to inflammatory stimuli. Here, we investigate the effect of age on the responsiveness of bone marrow-derived macrophages (BMDMs) to LPS and IFNγ. The context for addressing this question is that macrophages, which infiltrate the brain of aged animals, will encounter the neuroinflammatory environment that has been described with age.