Structural and Functional Changes in Pulmonary Macrophages and Lungs of Mice Infected with Influenza Virus A/H5N1 A/goose/Krasnoozerskoye/627/05

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• 作者：A. V. Kovner (1)
  A. G. Anikina (1)
  O. V. Potapova (1) potapova@soramn.ru
  T. V. Sharkova (1)
  L. A. Cherdanceva (1)
  V. A. Shkurupy (1)
  A. M. Shestopalov (2)
• 关键词：Key Words influenza virus A/H5N1 (A/goose/Krasnoozerskoye/627/05) &#8211 ; lungs &#8211 ; macrophages &#8211 ; early fibrosis &#8211 ; immunomorphological study
• 刊名：Bulletin of Experimental Biology and Medicine
• 出版年：2012
• 出版时间：June 2012
• 年：2012
• 卷：153
• 期：2
• 页码：229-232
• 全文大小：407.0 KB
• 参考文献：1. O. V. Potapova, V. A. Shkurupy, T. V. Sharkova, et al., Byull. Eksp. Biol. Med., 150, No. 12, 650–654 (2010).
  2. T. Burster, T. Giffon, M. E. Dahl, et al., Int. Immunol., 19, No. 5, 645–655 (2007).
  3. K. F. To, P. K. Chan, K. F. Chan, et al., J. Med. Virol., 63, No. 3, 242–246 (2001).
  4. J. Zhou, H. K. Law, C. Y. Cheung, et al., J. Infect. Dis., 193, No. 7, 945–953 (2006).
• 作者单位：1. Research Center of Clinical and Experimental Medicine, Siberian Division of the Russian Academy of Medical Sciences, Novosibirsk, Russia2. State Research Center 鈥淰ektor鈥? Novosibirsk oblast, Kol鈥檛sovo, Russia
• ISSN：1573-8221

文摘

C57Bl/6 mice were intranasally infected with influenza virus A/H5N1 A/goose/Krasnoozerskoye/627/05. The mortality rate of animals reached 70% on day 14 of the disease. The lungs of animals were characterized by necroses, destruction of vessels, hemorrhagic and thrombotic complications, edematous syndrome, and early fibrosis of the interstitium. On days 6-10 after infection, fibrosis was found in the zones of postnecrotic inflammatory infiltration. The expression of lysozyme and myeloperoxidase by pulmonary macrophages was initially increased, but decreased on day 10 of the study. The number of cathepsin D-expressing macrophages was elevated up to the 10th day of examination.