Expression of Complement Components and Regulators by Different Subtypes of Bone Marrow-Derived Macrophages

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• 作者：Chang Luo (1)
  Mei Chen (1)
  Angelina Madden (1)
  Heping Xu (1) heping.xu@qub.ac.uk
• 关键词：KEY WORDS macrophages &#8211 ; complement &#8211 ; cytokines &#8211 ; inflammation
• 刊名：Inflammation
• 出版年：2012
• 出版时间：August 2012
• 年：2012
• 卷：35
• 期：4
• 页码：1448-1461
• 全文大小：483.5 KB
• 参考文献：1. Ganz, T. 2011. Hepcidin and iron regulation, 10 years later. Blood 117: 4425–4433.
  2. Henson, P.M., and D.A. Hume. 2006. Apoptotic cell removal in development and tissue homeostasis. Trends in Immunology 27: 244–250.
  3. Lee, K.M., and S.Y. Seong. 2009. Partial role of TLR4 as a receptor responding to damage-associated molecular pattern. Immunology Letters 125: 31–39.
  4. Chen, G.Y., and G. Nunez. 2010. Sterile inflammation: sensing and reacting to damage. Nature Reviews Immunology 10: 826–837.
  5. Mosser, D.M., and J.P. Edwards. 2008. Exploring the full spectrum of macrophage activation. Nature Reviews Immunology 8: 958–969.
  6. Martinez, F.O., L. Helming, and S. Gordon. 2009. Alternative activation of macrophages: an immunologic functional perspective. Annual Review of Immunology 27: 451–483.
  7. Martinez, F.O., A. Sica, A. Mantovani, and M. Locati. 2008. Macrophage activation and polarization. Frontiers in Bioscience 13: 453–461.
  8. Laufer, J., Y. Katz, and J.H. Passwell. 2001. Extrahepatic synthesis of complement proteins in inflammation. Molecular Immunology 38: 221–229.
  9. Luo, C., M. Chen, and H. Xu. 2011. Complement gene expression and regulation in mouse retina and retinal pigment epithelium/choroid. Molecular Vision 17: 1588–1597.
  10. Copland, D.A., K. Hussain, S. Baalasubramanian, T.R. Hughes, B.P. Morgan, H. Xu, A.D. Dick, and L.B. Nicholson. 2010. Systemic and local anti-C5 therapy reduces the disease severity in experimental autoimmune uveoretinitis. Clinical and Experimental Immunology 159: 303–314.
  11. Reis, E.S., J.A. Barbuto, and L. Isaac. 2007. Complement components, regulators and receptors are produced by human monocyte-derived dendritic cells. Immunobiology 212: 151–157.
  12. Hinglais, N., M.D. Kazatchkine, C. Mandet, M.D. Appay, and J. Bariety. 1989. Human liver Kupffer cells express CR1, CR3, and CR4 complement receptor antigens. An immunohistochemical study. Laboratory Investigation 61: 509–514.
  13. Helmy, K.Y., K.J. Katschke Jr., N.N. Gorgani, N.M. Kljavin, J.M. Elliott, L. Diehl, S.J. Scales, N. Ghilardi, and M. van Lookeren Campagne. 2006. Crig: a macrophage complement receptor required for phagocytosis of circulating pathogens. Cell 124: 915–927.
  14. de Ceulaer, C., S. Papazoglou, and K. Whaley. 1980. Increased biosynthesis of complement components by cultured monocytes, synovial fluid macrophages and skynovial membrane cells from patients with rheumatoid arthritis. Immunology 41: 37–43.
  15. Whaley, K. 1980. Biosynthesis of the complement components and the regulatory proteins of the alternative complement pathway by human peripheral blood monocytes. The Journal of Experimental Medicine 151: 501–516.
  16. Zhou, A.Q., M.J. Herriott, and R.W. Leu. 1991. Kinetics of the biosynthesis of complement subcomponent c1q by murine macrophages: LPS, immune complexes, and zymosan alone and in combination with interferon-gamma. Journal of Leukocyte Biology 50: 453–463.
  17. Zimmer, B., H.P. Hartung, G. Scharfenberger, D. Bitter-Suermann, and U. Hadding. 1982. Quantitative studies of the secretion of complement component C3 by resident, elicited and activated macrophages. Comparison with C2, C4 and lysosomal enzyme release. European Journal of Immunology 12: 426–430.
  18. Haga, S., T. Aizawa, T. Ishii, and K. Ikeda. 1996. Complement gene expression in mouse microglia and astrocytes in culture: comparisons with mouse peritoneal macrophages. Neuroscience Letters 216: 191–194.
  19. Ezekowitz, R.A., R.B. Sim, M. Hill, and S. Gordon. 1984. Local opsonization by secreted macrophage complement components. Role of receptors for complement in uptake of zymosan. The Journal of Experimental Medicine 159: 244–260.
  20. Huang, Y., P.M. Krein, D.A. Muruve, and B.W. Winston. 2002. Complement factor B gene regulation: synergistic effects of TNF-alpha and IFN-gamma in macrophages. Journal of Immunology 169: 2627–2635.
  21. Hogasen, A.K., K. Hestdal, and T.G. Abrahamsen. 1993. Granulocyte-macrophage colony-stimulating factor, but not macrophage colony-stimulating factor, suppresses basal and lipopolysaccharide-stimulated complement factor production in human monocytes. Journal of Immunology 151: 3215–3224.
  22. Strainic, M.G., J. Liu, D. Huang, F. An, P.N. Lalli, N. Muqim, V.S. Shapiro, G.R. Dubyak, P.S. Heeger, and M.E. Medof. 2008. Locally produced complement fragments C5a and C3a provide both costimulatory and survival signals to naive CD4+ T cells. Immunity 28: 425–435.
  23. Verschoor, A., M.A. Brockman, M. Gadjeva, D.M. Knipe, and M.C. Carroll. 2003. Myeloid C3 determines induction of humoral responses to peripheral herpes simplex virus infection. Journal of Immunology 171: 5363–5371.
  24. Lin, M., N. Yin, B. Murphy, M.E. Medof, S. Segerer, P.S. Heeger, and B. Schroppel. 2010. Immune cell-derived C3 is required for autoimmune diabetes induced by multiple low doses of streptozotocin. Diabetes 59: 2247–2252.
  25. Chen, M., J.V. Forrester, and H. Xu. 2011. Dysregulation in retinal para-inflammation and age-related retinal degeneration in CCL2 or CCR2 deficient mice. PLoS One 6: e22818.
  26. Gersuk, G.M., L.W. Razai, and K.A. Marr. 2008. Methods of in vitro macrophage maturation confer variable inflammatory responses in association with altered expression of cell surface dectin-1. Journal of Immunological Methods 329: 157–166.
  27. Schwaeble, W., M.K. Schafer, F. Petry, T. Fink, D. Knebel, E. Weihe, and M. Loos. 1995. Follicular dendritic cells, interdigitating cells, and cells of the monocyte-macrophage lineage are the C1q-producing sources in the spleen. Identification of specific cell types by in situ hybridization and immunohistochemical analysis. Journal of Immunology 155: 4971–4978.
  28. Marletta, M.A. 1989. Nitric oxide: biosynthesis and biological significance. Trends in Biochemical Sciences 14: 488–492.
  29. Aznar, C., C. Fitting, and J.M. Cavaillon. 1990. Lipopolysaccharide-induced production of cytokines by bone marrow-derived macrophages: dissociation between intracellular interleukin 1 production and interleukin 1 release. Cytokine 2: 259–265.
  30. Wallis, R., D.A. Mitchell, R. Schmid, W.J. Schwaeble, and A.H. Keeble. 2010. Paths reunited: initiation of the classical and lectin pathways of complement activation. Immunobiology 215: 1–11.
  31. Beinrohr, L., J. Dobo, P. Zavodszky, and P. Gal. 2008. C1, MBL-MASPS and C1-inhibitor: novel approaches for targeting complement-mediated inflammation. Trends in Molecular Medicine 14: 511–521.
  32. de Agostini, A., H.R. Lijnen, R.A. Pixley, R.W. Colman, and M. Schapira. 1984. Inactivation of factor xii active fragment in normal plasma. Predominant role of C-1-inhibitor. The Journal of Clinical Investigation 73: 1542–1549.
  33. Davis 3rd, A.E., F. Lu, and P. Mejia. 2010. C1 inhibitor, a multi-functional serine protease inhibitor. Thrombosis and Haemostasis 104: 886–893.
  34. Dick, A.D., D. Carter, M. Robertson, C. Broderick, E. Hughes, J.V. Forrester, and J. Liversidge. 2003. Control of myeloid activity during retinal inflammation. Journal of Leukocyte Biology 74: 161–166.
  35. Kuehn, M.H., C.Y. Kim, B. Jiang, A.V. Dumitrescu, and Y.H. Kwon. 2008. Disruption of the complement cascade delays retinal ganglion cell death following retinal ischemia-reperfusion. Experimental Eye Research 87: 89–95.
  36. Chen, M., E. Muckersie, C. Luo, J.V. Forrester, and H. Xu. 2010. Inhibition of the alternative pathway of complement activation reduces inflammation in experimental autoimmune uveoretinitis. European Journal of Immunology 40: 2870–2881.
  37. Zhang, Y., S. Liu, J. Liu, T. Zhang, Q. Shen, Y. Yu, and X. Cao. 2009. Immune complex/ig negatively regulate TLR4-triggered inflammatory response in macrophages through Fc gamma RIIb-dependent PGE2 production. Journal of Immunology 182: 554–562.
  38. Edwards, J.P., X. Zhang, K.A. Frauwirth, and D.M. Mosser. 2006. Biochemical and functional characterization of three activated macrophage populations. Journal of Leukocyte Biology 80: 1298–1307.
  39. Sironi, M., F.O. Martinez, D. D'Ambrosio, M. Gattorno, N. Polentarutti, M. Locati, A. Gregorio, A. Iellem, M.A. Cassatella, J. Van Damme, S. Sozzani, A. Martini, F. Sinigaglia, A. Vecchi, and A. Mantovani. 2006. Differential regulation of chemokine production by Fcgamma receptor engagement in human monocytes: association of CCL1 with a distinct form of M2 monocyte activation (M2b, type 2). Journal of Leukocyte Biology 80: 342–349.
  40. Anderson, C.F., and D.M. Mosser. 2002. Cutting edge: biasing immune responses by directing antigen to macrophage Fc gamma receptors. Journal of Immunology 168: 3697–3701.
  41. Mantovani, A., A. Sica, S. Sozzani, P. Allavena, A. Vecchi, and M. Locati. 2004. The chemokine system in diverse forms of macrophage activation and polarization. Trends in Immunology 25: 677–686.
  42. Longhi, M.P., C.L. Harris, B.P. Morgan, and A. Gallimore. 2006. Holding T cells in check—a new role for complement regulators? Trends in Immunology 27: 102–108.
  43. Fernandez-Centeno, E., G. de Ojeda, J.M. Rojo, and P. Portoles. 2000. Crry/p65, a membrane complement regulatory protein, has costimulatory properties on mouse T cells. Journal of Immunology 164: 4533–4542.
• 作者单位：1. Centre for Vision and Vascular Science, School of Medicine, Dentistry and Biomedical Sciences, Queen鈥檚 University Belfast, Grosvenor Road, BT12 6BA Belfast, UK
• ISSN：1573-2576

文摘

Under inflammatory conditions, macrophages can differentiate into different functional subtypes. We show that bone marrow-derived macrophages constitutively express different levels of various complement-related genes. The relative expression levels are C1qb > Crry > CFH > C3 > C1r > CFB > DAF1 > CD59a > C2 > C1INH > C1s > C4. Upon activation, the expression of C1r, C1s, C3, C2, CFB, and C1INH was up-regulated, and CFH, CD59a, and DAF1, down-regulated in M1 (induced by interferon-γ + lipopolysaccharides (LPS)) and M2b (induced by immune complex + LPS) macrophages. The expression of C4 and CFH was slightly up-regulated in interleukin (IL)-10-induced M2c macrophages. Complement gene expression in IL-4-induced M2a macrophages was weakly down-regulated as compared to resting M0 macrophages. Higher levels of C3, C1INH, and CFB but lower levels of CFH expression in M1 and M2b macrophage suggests that they may be involved in the alternative pathway of complement activation during inflammation.